Application of Acceptable Daily Intake Values in Nutrition Research Studies that Consider the Safety of Low-Calorie Sweeteners

Several recent publications on the intake of low-calorie sweeteners (LCSs) have compared intake data to the corresponding Acceptable Daily Intake (ADI) values. This indicates a use of ADI that may not be appropriate, since ADI is not meant to be considered a threshold for a safety concern at one moment in time. This may lead to misunderstanding of the safety of LCSs, and affect the potential of LCSs as effective tools for lowering added sugar intake.

The proposed project aims to evaluate the trends in application of ADI to LCS intake data, health-related research, and international government documents/evaluations. The study is designed to test the hypothesis that there is an increasing misapplication of ADI as a type of “safety intake threshold” for particular age groups, and to discuss the ramifications of such a trend. This project should help researchers and clinicians better understand both what is meant by an ADI and what limitations exist for safety determinations when comparing LCS intake data to an ADI. It should also help clinicians to better understand the safety of LCSs and the level of expected risk with use in various life stages.

Institution: ToxStrategies, Inc.
Principal Investigator: Daniele Wikoff, PhD
Amount Awarded: $78,000
Year Awarded: 2019

Read more: Use of Acceptable Daily Intake (ADI) as a Health-Based Benchmark in Nutrition Research Studies that Consider the Safety of Low-Calorie Sweeteners (LCS): a Systematic Map

View this project on the Center for Open Science's Open Science Framework.

Learn more about the IAFNS Low-Calorie Sweeteners Committee.