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Assessing the Relationship between Low-Calorie Sweetener Use and Quality of Life Measures in Adults with Type 1 Diabetes

Low- and No- calorie sweeteners (LNCSs) have been acknowledged as a tool for reducing the intake of total carbohydrates and particularly added sugars in the nutritional management of diabetes. LNCSs may also help to improve Quality of Life (QoL). QoL is an important aspect in management of diabetes as reduced QoL can negatively affect diabetes-related […]

Broader Dietary Value of Food Category Contributors to Sodium Intake

As noted in the 2020 Dietary Guidelines Advisory Committee report, there is significant overlap between food categories that contribute to sodium intake and to vegetable intake. To ensure appropriate and effective messaging, dietary guidance, and food development or modification, it is important to understand the totality of nutrients and food groups provided by commonly consumed […]

Impact of Ingested Live Microbes on Health: An evidence Map

Human gut microbiome research has linked imbalances in the gut microbiota with several suboptimal health conditions. Consequently, the application of dietary interventions including foods (i.e., fermented foods [FFs]) and food supplements (i.e., probiotics) that contain live microorganisms to positively impact the gut microbiota and, in turn, health, has been the subject of much attention. Evidence […]

The Identification of Microbially-Derived Metabolites as Biomarkers: What Changes of Which Metabolites Matter for Health?

Identifying microbially‐derived metabolites that may serve as biomarkers for health, or metabotyping, is a necessary step to understanding the role of the microbiome in human health. Ultimately, knowing what metabolites (including presence and quantity) matter for health can inform development of a nutritional strategy for health benefits and the prevention of adverse health outcomes such […]

Development of a Research Framework for Evidence-Based Assessment of Potential Carcinogens in Human Diets

Risk assessment of chemicals that are potentially carcinogenic in humans often relies on extrapolation from carcinogenicity bioassays. There is a growing belief in the scientific community that evidence-based risk assessment can replace historical, over-protective guidance-based approaches. However, there is no consensus within the scientific community on an approach or framework for the application of an […]

Effect of Low-Calorie Sweetener Intake on Glycemic Response

Globally, dietary guidance recommends reducing added and total sugars in the diet to reduce caloric intake and chronic disease. Low-calorie sweeteners (LCS) present an option for reducing calories while providing sweetness in the diet, but questions remain regarding the effects of LCS on health, including its effects on glycemic response and diabetes. This project will […]

Standardizing Method and Development of Normal Values to Measure Human Small Intestinal and Colonic Permeability

Maintaining—or restoring to normal—gut barrier function is not currently recognized as a physiologic benefit of fiber consumption, in part due to lack of agreement by experts in the field on how to define and measure normal gut barrier function in human nutrition research. An IAFNS sponsored expert panel published an article in 2019 summarizing the […]

Metabolic and Physiological Properties of Rare Sugars Review Paper

Rare sugars are monosaccharides or disaccharides that exist in small quantities in nature and have unique metabolic and physiological properties that help distinguish them from more commonly consumed sugars like fructose and glucose. Due to their unique properties, rare sugars offer potential health benefits as part of an overall healthy diet pattern, including slower intestinal […]