Partially Hydrogenated Oils: Dose Response Evaluation

There is evidence of a significant dose-dependent linear relationship between industrial trans fatty acids (iTFA) intake from partially hydrogenated oils and low-density lipoprotein cholesterol (LDL-C), a validated surrogate marker of coronary heart disease risk. The aim of this study is to conduct a meta-regression of controlled clinical trial data to investigate quantitatively the relationship between dietary intake of iTFAs and increased LDL-C, and to systematically consider the data relating to the mode of action for the effects of iTFAs on plasma LDL-C levels.

Institution: Toxicology Excellence for Risk Assessment
Principal Investigator: Lynne Haber, PhD
Amount Awarded: $203,400
Year Awarded: 2015

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Mode-of-action evaluation for the effect of trans fatty acids on low-density lipoprotein cholesterol
Meta-regression analysis of the effect of trans fatty acids on low-density lipoprotein cholesterol

View Part 1 of this project: Trans Fatty Acids and Cholesterol Levels: An Evidence Map of the Available Science

Learn more about the IAFNS Partially Hydrogenated Oils Committee.

Trans Fatty Acids and Cholesterol Levels: An Evidence Map of the Available Science

The aim of this project is to characterize the existing literature regarding intervention trials on industrial trans fatty acid intake as a substitute for cis-monounsaturated fatty acids or saturated fatty acids and resulting changes in LDL- or HDL-cholesterol.

Institution: Biofortis
Principal Investigator: DeAnn Liska, PhD
Amount Awarded: $36,500
Year Awarded: 2014

Read more:
Trans fatty acids and cholesterol levels: An evidence map of the available science

View Part 2 of this project: Partially Hydrogenated Oils: Dose Response Evaluation

Learn more about the IAFNS Partially Hydrogenated Oils Committee.