Development of a Human Whole-Stool Reference Material – NIST Collaboration

Over the past 10+ years, it has become evident that the human gut microbiome plays a critical role in a vast and disparate set of health and disease states; including diabetes, obesity, cancer and depression. To identify new biomarkers that may serve as disease indicators and to understand biologically‐relevant properties of the human gut microbiome, validated measurements that accurately describe various properties of the microbial community, both quantitatively and qualitatively, are needed. The aim of this project is to develop a set of Human Whole Stool Reference Materials that are certified by the National Institute for Standards and Technology (NIST) for clinically-relevant metabolites. The set will be derived from a small cohort of donors who are selected based on their health or disease state (e.g. obesity vs. healthy, diet controlled, etc.). IAFNS is collaborating with NIST to develop a list of metabolites with likely relevance for health, that would be useful to include/measure in the material.

Institutions: The National Institute for Standards and Technology, BioIVT

Principal Investigator: The National Institute for Standards and Technology

Amount: $73,450

Year: 2022

Read more: Workshop Report: Toward The Development Of A Human Whole Stool Reference Material For Metabolomic And Metagenomic Gut Microbiome Measurements

This work was supported by the IAFNS Gut Microbiome Committee.