Beyond Science and Decisions: From Problem Formulation to Dose-Response Assessment
Virtual and In Person, Event
February 15, 2022 – February 17, 2022
Since 2010, the Alliance for Risk Assessment has sponsored a workshop series titled Beyond Science & Decisions: From Problem Formulation to Comprehensive Risk Assessment. Building on the ideas of the National Academy of Sciences’ (NAS) Science & Decisions: Advancing Risk Assessment (2009), twelve previous workshops brought together over 60 organizations seeking to advance the NAS recommendations.
Over 50 presented case studies have thus far contributed to an expanding compendium of practical, problem-driven approaches for “fit for purpose” risk assessments. As a resource for regulators and scientists, the compendium details key considerations for applying relevant dose-response or exposure assessment methods, whether novel or evolving, and links these methods to specific problems faced by risk assessors and risk managers in a variety of organizations (e.g., local, regional and federal governments, academia, private sector).
The objectives of Workshop XIII include:
Use a multi-stakeholder approach to share information supporting the development of practical problem-driven risk assessment methods
Highlight effective and meaningful context-specific problem formulation approaches that apply an appropriate level of detail
Promote hazard identification, dose-response, exposure assessment, and risk characterization methods, such as those that:
o Reflect relevant biology (including dose-dependent transitions) and mode of action
o Describe assumptions, strengths, and limitations of relevant data and address key considerations in risk assessment and decision-making
o Use new approaches to advance the 3’Rs (replace, reduce, and refine animal use in research)
o Consider population and human variability, including underlying disease and exposure conditions
o Quantitative or qualitative uncertainty analysis.