Workshop on Best Practices for Studies of Diet and the Intestinal Microbiome
Bethesda, MD, USA
June 13, 2017 – June 14, 2017
Natcher Conference Center - NIH Campus
The purpose of this workshop is to improve rigor and reproducibility in research on the colonic microbiome, identify important dietary information that should be reported and parameters to consider in design of studies, particularly for clinical studies on diet and the intestinal microbiome. A summary for the research community will be published in a peer-reviewed journal.
More information on this workshop can be found on the NIH Website.
Agenda – 13 June
Welcome and Introductions
David Klurfeld, USDA ARS
Gregory G. Germino, M.D., Deputy Director, NIDDK
Session I – Characterization of dietary fibers and other nutrients that feed the microbiome
Keynote Talk: Chemical and physical characteristics of dietary fibers that affect their utilization by the gut microbiota and the host
George Fahey, University of Illinois
The broad range of structures of dietary fibers and their specificity to bacterial fermentation
Bruce Hamaker, Purdue University
Fiber-microbiome effects on health and disease: connecting real foods with specific microbial responses
Eric Martens, University of Michigan
Session II – Animal Models
Keynote Talk: Diet-microbiota dynamics: leveraging animal models to hasten translatable discovery
Justin Sonnenburg
The role of gut microbial and host circadian rhythms in metabolic health and disease
Eugene Chang, University of Chicago
Prebiotic action of food polyphenols on gut microbiota to alleviate obesity-linked inflammatory diseases
Andre Marette, University of Laval
Food additives and microbiota interactions in the etiology of intestinal inflammation
Benoit Chassaing, Georgia State University
Utility of Non-Rodent Models for Gastrointestinal Microbiome Research
Kelly Swanson, University of Illinois
General Discussion on nutrients affecting microbiome and animal models
Agenda- 14 June
Welcome and Introductions
David Klurfeld, USDA ARS
Griffin P. Rodgers, M.D., M.A.C.P., Director, NIDDK
Session III -In Vitro Models
Culturing gut microbial ecosystems in vitro: using bioreactors as model systems
Emma Allen-Vercoe, University of Guelph
Effect of host diet on fecal fermentation outcomes
Devin Rose, University of Nebraska
General Discussion on in vitro models
Session IV – Human Studies
Keynote Talk: Impact of diet on the human gut microbiome and its metabolome: relevance to health and disease
Gary Wu
What are the ideal fiber requirements for humans?
Stephen O’Keefe, University of Pittsburgh
Effect of diet on gut microbiota
Maria Saarela, VTT Finland
Nutrients vs diets: using controlled feeding studies to evaluate diet-microbiome interactions in humans
Johanna Lampe, Fred Hutchinson Cancer Center
Beyond dietary fiber: foods, food additives, and supplements that alter gut bacteria
Joanne Slavin, University of Minnesota
Regulatory considerations in diet and microbiome studies
Barbara Schneeman, FDA (retired)
General Discussion: identification of critical dietary issues for design and reporting, terminology (e.g., fiber, prebiotics), research gaps that should be addressed in all studies of diet and gut microbiome, any issues remaining from previous discussions. Challenges in relating models to human situation.