Dietary bioactives are food substances that promote health but lack quantified intake recommendations because they are not characterized as essential to prevent well characterized deficiency conditions. A newly released guideline by the Academy of Nutrition and Dietetics recommends the quantity of flavan-3-ols to help adults maintain cardiovascular health. The recommendation translates evidence from a comprehensive systematic evidence review by Raman et al. using the AND guideline development process and applying a recently released (ASN endorsed) framework for developing recommended intakes of bioactive substances. The quantified recommended intake of flavan-3-ols to promote cardiovascular health is the culmination of grants provided by IAFNS to support the evidence review, framework development, and finally the independent AND guideline development process and publication. Please contact IAFNS if your professional health organization is interested in translating evidence for additional dietary bioactives.