Reducing the potential impact of heavy metals on health includes addressing their presence in human diets. However this is a challenging task since metals can unavoidably enter the food supply from various routes such as soil, water and air. A new IAFNS grant provides resources to develop a framework for the prioritization of heavy metals based on risk and mitigation efficacy and impact. This project will investigate how a structured approach can be developed to prioritizing heavy metals in commodities based on both risk factors and mitigation opportunities to reduce the presence of heavy metals in human diets to the lowest extent possible. The project will also align with FDA’s Closer to Zero action plan to minimize heavy metals in baby and infant food.