The Caffeine Committee promotes scientific evaluation of health and safety issues related to caffeine consumption and serves as a resource for reliable science on caffeine to support the advancement of public health.

Systematic Review Now Available:

Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children.

Selected as the "Best Paper of the Year” by the editors of Food and Chemical Toxicology.

Access the Caffeine Systematic Review Resource Page

Why is this research valuable?

The Committee conducted a systematic evidence-based review of the health effects associated with the consumption of caffeine in humans to update the 2003 Nawrot et al. review. Since this time, more than 10,000 papers have been published related to caffeine—approximately 5,000 of such address effects or exposure in humans. It is critical that this new body of literature be evaluated to reflect the current state of the science. The systematic review followed the Institute of Medicine (IOM) Framework, “Finding What Works in Health Care—Standards for Systematic Reviews.” An independent scientific advisory board was formed to undertake this work. The review looked specifically at adverse health outcomes related to caffeine, general toxicity, physiological effects, cardiovascular, bone and calcium, behavior, and reproductive and developmental endpoints and pharmacokinetics. Individual protocols for the review of each of these endpoints has been published on the PROSPERO registration for systematic reviews.  Each protocol can be found by following the link for each of the endpoints:

COMMITTEE MEMBERS
Applied Food Sciences, Inc.
Keurig Dr Pepper​
Kraft Heinz Company
Red Bull GmbH

ACADEMIC ADVISOR
Marilyn Cornelis, PhD, Northwestern University Feinberg School of Medicine

GOVERNMENT ADVISOR
Harris Lieberman, PhD, Military Nutrition Division
U.S. Army Research Institute of Environmental Medicine (USARIEM)

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Projects Supported by the Committee:

Key Findings and Implications of a Recent Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children

Systematic Review of the Health Effects Associated with Consumption of Caffeine in Humans

Publications

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Key Findings and Implications of a Recent Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children

Nutrients, 2018

This paper is a “plain language summary” of the comprehensive 2017 systematic review on the adverse health outcomes associated with caffeine in healthy adults, pregnant women, adolescents and children. The authors of the systematic review were invited to develop this summary by the co-editors of Nutrients, for inclusion in a special journal issue on caffeine.

Read more about Key Findings and Implications of a Recent Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children

Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children

Food and Chemical Toxicology, 2017

This Systematic Review looked at five adverse health outcomes associated with caffeine consumption and over 2 dozen specific endpoints related to caffeine in the areas of: acute toxicity, cardiovascular effects, bone and calcium, behavior reproductive & development toxicity.

Read more about Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children

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							Official Program
					
			About this session
							Expand
		
While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews", as a case study.


There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., "Effects of caffeine on human health", there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.


The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.


Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

			Agenda & Videos
							Expand
		
Welcome

Alison Kretser, MS, RD, IAFNS
The Caffeine Landscape - framing the need for the Systematic Review 

Dennis Keefe, PhD, FDA

Video
Striving for the Gold Standard in the Systematic Review Process

Esther Myers, PhD, RDN, FAND, EF Myers Consulting

Video
The Methodology and Challenges of the Caffeine Systematic Review

Daniele Wikoff, PhD, ToxStrategies

Video
Q&A

Moderated by Dennis Keefe, PhD

Video

10:10 - 10:25 Break

General Results of the Systematic Review

Daniele Wikoff, PhD, ToxStrategies

Video

Results of Specific Health Endpoints- Scientific Advisory Board Members


    

  • Harris Lieberman, US Army - Behavior - Video 
    • 

  • Charles O'Brien, University of Pennsylvania - Behavior - Video (See Lieberman for pdf)
    • 

  • Jennifer Peck, PhD University of Oklahoma - Reproductive & Developmental Toxicity - Video 
    • 

  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine- Cardiovascular - Video 
    • 

  • Connie Weaver, PhD, Purdue University - Bone & Calcium - Video 
    • 

  • Milton Tenenbein, MD, University of Manitoba - Acute & Pharmacokinetics - Video 
    • 


Panel Discussion with the Caffeine Systematic Review Project Team Members Video

Moderated by Dennis Keefe, PhD

Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of IAFNS (Oversight Committee)
Overall Conclusions - presented by Daniele Wikoff

Full session playlist 
				CoffeeBambooSmall
	

See IAFNS's other sessions at Experimental Biology 2017:

			
							Full Schedule
					
	
			
							Learn more
					


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The events below were organized by IAFNS.  To access the entire conference program, visit the Experimental Biology website.

Conducting a Systematic Review for a Global Audience: Challenges in Merging Nutrition and Toxicological Evidence for a Safety Assessment of Caffeine

Saturday, 22 April 2017

 8:30AM - 12:30PM

Ballroom S100BC

 Speakers: Dennis Keefe, FDA; Harris Lieberman, USARIEM; Esther Myers, EF Myers Consulting; Charles O'Brien, University of Pennsylvania; Jennifer Peck, University of Oklahoma; Milton Tenenbein, University of Manitoba; Connie Weaver, Purdue University; Daniele Wikoff, ToxStrategies

Supported by the IAFNS Caffeine Working Group

Session Info & Videos
The Changing Brain: How Brain Plasticity, Exercise and Nutrition Affect Function and Cognition

Saturday, 22 April 2017

3:00PM - 5:00PM,

Ballroom S100BC

    

  • Neurogensis and brain plasticity in the adult brain - Henriette van Praag, National Institute on Aging; 
    • 

  • The Relation of Exercise, fitness, & Adiposity to Cognitive and Brain Health - Charles Hillman, University of Illinois - Video
    • 

  • Neuroinflammatory Processes in Cognitive Disorders - Sophie Laye, Universite Bordeaux - Video
    • 

  • Exercise, Nutrition and Brain Funciton: What are the steps toward dietary and physical activity Recommendations? - Mary Ann Johnson, University of Georgia - Video
    • 

  • Panel Discussion - Video
    • 



Utility of Predictive Modeling for Nutrition Research, Clinical Interventions and Public Health

Sunday, 23 April 2017

 8:30AM- 10:30AM

 S105BCD

Speakers:

    

  • Intro to Predictive Modeling: From Linear Regression Models to Mechanistic Mathematical Modeling - David Allison, University of Alabama at Birmingham - Video; 
    • 

  • Use of Predictive Modeling in the Design of Clinical Studies Kevin Hall, NIDDK - Video; 
    • 

  • Application of Predictive Modeling in Weight Loss Counseling -  Corby Martin, Pennington Biomedical Research Center - Video; 
    • 

  • Application of Predictive Modeling in Personalized Nutrition - Ben van Ommen, TNO - Video;
    • 

  • Utility of PRedictive Modeling for Public Health Obesity Policies - Emily Dhurandhar, Texas Tech University - Video; 
    • 

  • Summary and Wrap-Up - Diana Thomas, West Point - Video
    
Supported by the IAFNS Protein Committee
    • 

  • Full session playlist
    • 


Learning Lab: How to Access and Use a Fiber and Health Outcomes Database for Researchers and Policymakers

Tuesday, 25 April 2017

 11:00AM - 12:30PM

 S105AB

 Speakers: Kara Livingston, Tufts University; Caleigh Sawicki, Tufts University

Supported by the IAFNS Carbohydrate Committee
Posters

Sources of dietary folate/folic acid in women of different races in the United States between 2009 and 2012: What is the role of fortified and enriched products?

PDF

Abstract Number: 6707

 Poster Board Number C88

 Presenter: Ray DeVirgiliis, George Washington University

 Monday, 24 April

 1:45PM-2:45PM


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