The Caffeine Committee promotes scientific evaluation of health and safety issues related to caffeine consumption and serves as a resource for reliable science on caffeine to support the advancement of public health.

Systematic Review Now Available:

Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children.

Selected as the "Best Paper of the Year” by the editors of Food and Chemical Toxicology.

Access the Caffeine Systematic Review Resource Page

Why is this research valuable?

The Committee conducted a systematic evidence-based review of the health effects associated with the consumption of caffeine in humans to update the 2003 Nawrot et al. review. Since this time, more than 10,000 papers have been published related to caffeine—approximately 5,000 of such address effects or exposure in humans. It is critical that this new body of literature be evaluated to reflect the current state of the science. The systematic review followed the Institute of Medicine (IOM) Framework, “Finding What Works in Health Care—Standards for Systematic Reviews.” An independent scientific advisory board was formed to undertake this work. The review looked specifically at adverse health outcomes related to caffeine, general toxicity, physiological effects, cardiovascular, bone and calcium, behavior, and reproductive and developmental endpoints and pharmacokinetics. Individual protocols for the review of each of these endpoints has been published on the PROSPERO registration for systematic reviews.  Each protocol can be found by following the link for each of the endpoints:

COMMITTEE MEMBERS
Applied Food Sciences, Inc.
Keurig Dr Pepper​
Kraft Heinz Company
Red Bull GmbH

ACADEMIC ADVISOR
Marilyn Cornelis, PhD, Northwestern University Feinberg School of Medicine

GOVERNMENT ADVISOR
Harris Lieberman, PhD, Military Nutrition Division
U.S. Army Research Institute of Environmental Medicine (USARIEM)

Join Us!

Projects Supported by the Committee:

Beverage Caffeine Intake Study

Key Findings and Implications of a Recent Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children

Systematic Review of the Health Effects Associated with Consumption of Caffeine in Humans

Publications

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Key Findings and Implications of a Recent Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children

Nutrients, 2018

This paper is a “plain language summary” of the comprehensive 2017 systematic review on the adverse health outcomes associated with caffeine in healthy adults, pregnant women, adolescents and children. The authors of the systematic review were invited to develop this summary by the co-editors of Nutrients, for inclusion in a special journal issue on caffeine.

Read more about Key Findings and Implications of a Recent Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children

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Events

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Beyond the Headlines: Communicating the Science of Caffeine

March 21, 2022

Virtual, Webinar

This webinar is designed for practitioners who seek to enhance their understanding of the science of caffeine and how to communicate evidence-based messaging to consumers. Participation in this webinar will support the ability of practitioners to evaluate the science of caffeine for various populations and respond to consumer perceptions related to its safety.

Read more about Beyond the Headlines: Communicating the Science of Caffeine

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