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The Identification of Microbially-Derived Metabolites as Biomarkers: What Changes of Which Metabolites Matter for Health?
Identifying microbially‐derived metabolites that may serve as biomarkers for health, or metabotyping, is a necessary step to understanding the role of the microbiome in human health. Ultimately, knowing what metabolites (including presence and quantity) matter for health can inform development of a nutritional strategy for health benefits and the prevention of adverse health outcomes such […]
Development of a Research Framework for Evidence-Based Assessment of Potential Carcinogens in Human Diets
Risk assessment of chemicals that are potentially carcinogenic in humans often relies on extrapolation from carcinogenicity bioassays. There is a growing belief in the scientific community that evidence-based risk assessment can replace historical, over-protective guidance-based approaches. However, there is no consensus within the scientific community on an approach or framework for the application of an […]
Significant knowledge exists about sodium reduction in foods, some of which is captured in Food & Drug Administration guidance documents. But progress made to date has not been captured in a publicly accessible format, and where it is available, it is not in a domain typically accessed by the public health community. Developing a compendium […]
Impact of Dietary Sweetness Exposure on Future Dietary Intake: Reanalysis of Existing Intervention Trial Data
Several global health authorities recommend avoidance of sweetness in the diet from both sugar and low-calorie or non-nutritive sweeteners, due to concerns that intake of sweet taste drives a preference for more sweetness, with ultimate negative consequences for energy intake and weight. However, the scientific data available to understand the role of sweetness in the […]
Globally, dietary guidance recommends reducing added and total sugars in the diet to reduce caloric intake and chronic disease. Low-calorie sweeteners (LCS) present an option for reducing calories while providing sweetness in the diet, but questions remain regarding the effects of LCS on health, including its effects on glycemic response and diabetes. This project will […]
Standardizing Method and Development of Normal Values to Measure Human Small Intestinal and Colonic Permeability
Maintaining—or restoring to normal—gut barrier function is not currently recognized as a physiologic benefit of fiber consumption, in part due to lack of agreement by experts in the field on how to define and measure normal gut barrier function in human nutrition research. An IAFNS sponsored expert panel published an article in 2019 summarizing the […]
Rare sugars are monosaccharides or disaccharides that exist in small quantities in nature and have unique metabolic and physiological properties that help distinguish them from more commonly consumed sugars like fructose and glucose. Due to their unique properties, rare sugars offer potential health benefits as part of an overall healthy diet pattern, including slower intestinal […]
The wide range of methods used to describe the impact of food on short-term glycemic response makes it challenging to apply research results broadly, including but not limited to its use on food labels. The choice of approach should be informed by selecting a validated method that translates into a meaningful consumer and public health […]
The IAFNS Food and Chemical Safety Committee invests in the training and education of future scientists and leaders in the fields of food and chemical safety and food toxicology by supporting a Summer Fellowship Program for doctoral students. This project focuses on updating the Metal Dietary Exposure Screening Tool. Detection of heavy metals at trace […]
Effect of the Use of Potassium-Based Sodium Replacers on Sodium and Potassium Intakes of the US Population
Sodium intake in the US population exceeds recommendations, and efforts have long been underway to reduce the amount of sodium in foods. Salt in the form of NaCl is the largest source of sodium in processed foods. Given the particular roles NaCl plays in foods (functional, taste, food preservation), it is difficult to remove it […]
Current dietary recommendations for protein intake are expressed as grams per kilogram of body weight in recognition of its role as the structural building blocks for lean body mass. Although FAO/WHO acknowledges that this recommendation is appropriate for those in the ideal weight-for-height ranges, it may not be appropriate for those who are overweight. This […]
Heavy rainfall and flooding following a hurricane can massively impact water quality, especially via runoff from agricultural and industrial operations. The IAFNS Food Microbiology Committee is supporting researchers at North Carolina State University to examine the emergence, potential routes of contamination and proliferation, as well as virulence and susceptibility of three major foodborne pathogens in […]