The Gut Microbiome Committee advances the science required to substantiate dietary modulation of the gut microbiome in ways that are conducive to health.

Why is this research valuable?

Over the past 10 years, focus on the gut microbiome and health has increased exponentially. However, there remain a growing number of unanswered questions, including best methods for understanding and documenting the effects of dietary components on specific aspects of the gut microbiome. Harmonization of methods will support development of a consensus on biomarkers and endpoints required to characterize diet-gut microbiome-health relationships to support evidence-based dietary recommendations.

One example is our collaboration with NIST (the National Institute of Standards and Technology) to develop a human whole stool reference material. Check out this video which summarizes the effort.

Current Work

Webinar Series

The Gut Microbiome Committee has initiated a webinar series to help guide the committee’s research and projects.

COMMITTEE MEMBERS

Abbott Nutrition
Biofortis, Merieux NutriSciences
DSM Nutritional Products
GSK
General Mills
Kellogg Company
Kraft Heinz Company
Mondelēz International
National Dairy Council

ACADEMIC ADVISORS

Johanna Lampe, PhD, Fred Hutchinson Cancer Research Center
Mary Ellen Sanders, PhD, International Scientific Association for Probiotics and Prebiotics
Kelly Swanson, PhD, University of Illinois at Urbana-Champaign

GOVERNMENT ADVISORS

Cindy Davis, PhD, US Department of Agriculture, ARS
Barbara Schneeman, PhD, US Food and Drug Administration (retired)
Lauren VieBrock, PhD, US Food and Drug Administration
William Yan, PhD, Health Canada

Publications

All Publications

Workshop Report: Toward the Development of a Human Whole Stool Reference Material for Metabolomic and Metagenomic Gut Microbiome Measurements

This report represents the consensus opinions of workshop participants on developing general criteria for metabolite selection and a preliminary list of proposed metabolites. The paper describes some of the strengths and limitations of this initiative given the current state of gut microbiome research.

Read more about Workshop Report: Toward the Development of a Human Whole Stool Reference Material for Metabolomic and Metagenomic Gut Microbiome Measurements

Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions

IAFNS previously took on the task of defining a “healthy gut microbiome,” and the outcome of this effort was published by Backhed et al. in 2012. Since that time, the body of work on gut microbiome has grown exponentially. In 2018, >40 invited academic, government, and industry experts gathered to evaluate progress toward this definition and explore the question: Can a Healthy Gut Microbiome be Defined Through Quantifiable Characteristics?

Read more about Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions

Considerations for Best Practices in Studies of Fiber or Other Dietary Components and the Intestinal Microbiome

Proceedings from a 2-day workshop organized by the National Institutes of Health and U.S. Department of Agriculture that included 16 presentations focused on the role of diet in alterations of the gastrointestinal microbiome, primarily that of the colon.

Read more about Considerations for Best Practices in Studies of Fiber or Other Dietary Components and the Intestinal Microbiome

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Events

Learnings and Challenges Developing the Largest Gut Microbiome Discovery Platform — From Bench to Commercial Application

Virtual, Event

Ten years ago, two scientists had a hypothesis that the body’s glycemic response to food was personalized and due to not just food, but the person eating the food.  To prove their hypothesis they conducted the largest nutrition trials ever conducted and demonstrated that the gut microbiome has meaningful predictive value.

Read more about Learnings and Challenges Developing the Largest Gut Microbiome Discovery Platform — From Bench to Commercial Application

NUTRITION 2021

Virtual, Event

Food Biome to Human Biome: Beyond Nutrients

Gut microbiota is intertwined with host metabolism, immune function, and psychological state. Learn how foods we consume are one of the main drivers that shift microbiota profile and functionalities.

Read more about NUTRITION 2021

The One You Feed: Identifying Specific Interactions of Dietary Fiber Structures and the Microbiota That Ferment Them

Virtual, Webinar

The gut microbiome is known to respond rapidly to dietary changes, but the idiosyncrasy and dynamics of individuals’ gut microbiota make predictive understanding of the impact of diet on the structure and function of gut microbiota elusive. Dietary fibers are increasingly appreciated for their role in preserving microbiome – and gut – health and this presentation will review recent research in the area.

Read more about The One You Feed: Identifying Specific Interactions of Dietary Fiber Structures and the Microbiota That Ferment Them

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