The Gut Microbiome Committee advances and disseminates the science to substantiate dietary modulation of the gut microbiome in ways that are conducive to health.
Why is this research valuable?
Over the past 20 years, focus on the gut microbiome and health has increased exponentially. However, there remain a growing number of unanswered questions, including best methods for understanding and documenting the effects of dietary components on specific aspects of the gut microbiome. Harmonization of methods will support development of a consensus on biomarkers and endpoints required to characterize diet-gut microbiome-health relationships to support evidence-based dietary recommendations.
Strategic Focus Area
- Establish foundational science to support future statements about the impact of nutrients, foods, and diets on health via the gut microbiome.
- Build clarity around properties of the gut microbiome that may be linked to health – and how these properties can be supported by diet.
- Advance the development of evidence related to the impact of beneficial live microbe intake on health.
- Support science-based healthcare practitioner messaging to patients and clients on the impact of diet on gut microbiome and health.
Current Work
This committee has various work underway:
Webinar Series
The Gut Microbiome Committee has initiated a webinar series to help guide the committee’s research and projects.
COMMITTEE MEMBERS
Abbott Nutrition
Haleon
General Mills
Mondelēz International
National Dairy Council
ACADEMIC ADVISORS
Johanna Lampe, PhD, RD, Fred Hutchinson Cancer Research Center
Mary Ellen Sanders, PhD, International Scientific Association for Probiotics and Prebiotics
Kelly Swanson, PhD, University of Illinois at Urbana-Champaign
GOVERNMENT ADVISORS
Cindy Davis, PhD, USDA, ARS
Barbara Schneeman, PhD, US FDA (retired)
Lauren VieBrock, PhD, US FDA
William Yan, PhD, Health Canada (Retired)
Projects Supported by the Committee:
Publications
Publication Date
All Publications
Diet-Related and Gut-Derived Metabolites and Health Outcomes: A Scoping Review.
Metabolites, 2022
Read more about Diet-Related and Gut-Derived Metabolites and Health Outcomes: A Scoping Review.
Global Regulatory Frameworks for Fermented Foods: A Review
Frontiers in Nutrition, 2022
The review provides important perspective and context in relation to current global fermented food regulatory practices with possible directions and recommendations for future legislative efforts.
Read more about Global Regulatory Frameworks for Fermented Foods: A Review
An Overview of Current Knowledge of the Gut Microbiota and Low-Calorie Sweeteners
Nutrition Today, 2021
This review provides an overview of the interrelationships among the diet, gut microbiota, and health status and then focuses specifically on published research assessing the relationship of low-/no-calorie sweeteners (LNCSs) to selected aspects of the gut microbiota.
Read more about An Overview of Current Knowledge of the Gut Microbiota and Low-Calorie Sweeteners
Workshop Report: Toward the Development of a Human Whole Stool Reference Material for Metabolomic and Metagenomic Gut Microbiome Measurements
Metabolomics, 2020
This report represents the consensus opinions of workshop participants on developing general criteria for metabolite selection and a preliminary list of proposed metabolites. The paper describes some of the strengths and limitations of this initiative given the current state of gut microbiome research.
Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions
The Journal of Nutrition, 2019
IAFNS previously took on the task of defining a “healthy gut microbiome,” and the outcome of this effort was published by Backhed et al. in 2012. Since that time, the body of work on gut microbiome has grown exponentially. In 2018, >40 invited academic, government, and industry experts gathered to evaluate progress toward this definition and explore the question: Can a Healthy Gut Microbiome be Defined Through Quantifiable Characteristics?
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Events
Diet-Microbiome Interactions in Older People: Effect on Inflammaging
May 18, 2023
Virtual, U.S.
Speaker: Paul O’Toole, PhD, Professor of Microbial Genomics and Head of Microbiology, University College Cork; Principal Investigator, APC Microbiome Ireland
Read more about Diet-Microbiome Interactions in Older People: Effect on Inflammaging
Live Microbe Data and How to Submit to the Global Branded Food Products Database
February 27, 2023
Virtual, Event
Food manufacturers can now include information on the amount of beneficial live microbes present in food products, specify the level (low, medium or high) of microbes and optionally indicate the microbe species. These data will support research on associations between beneficial live dietary microbes and health when linked to biomarkers of health and data on health outcomes.
Read more about Live Microbe Data and How to Submit to the Global Branded Food Products Database
Sample Collection, Preservation, and Data Analysis in Gut Microbiome Research: Current Methods and Potential Impact on Results
October 13, 2022
Virtual, Event
Part of the American Society for Nutrition’s NUTRITION 2022 Annual Satellite Series
In this session, the current state of knowledge related to sample collection, utility of standards, sequencing, and bioinformatic and biostatistical approaches will be reviewed by experts working in the field. Speakers will expand on how selection among the various methodological options can impact study results.
“Crash Course” on Design and Interpretation of Gut Microbiome Research
July 21, 2022
Virtual, Event
Effective application of gut microbiome research requires clinicians to critically appraise methodological elements of research when interpreting results. In this webinar, an overview of best practices for designing and conducting diet-microbiome research in humans will be provided. Topics will include not only intervention study designs but also recruitment tips, sampling methods, important metadata to collect, and more.
Read more about “Crash Course” on Design and Interpretation of Gut Microbiome Research
IAFNS at NUTRITION 2022
June 14, 2022 – June 16, 2022
Virtual, Event
Join IAFNS at the American Society for Nutrition Annual meeting – NUTRITION 2022 – to learn about some of our funded projects.
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Diet-Related and Gut-Derived Metabolites and Health Outcomes: A Scoping Review: Abstract Presentation Number: PO24-19-22 Expand Presenting Author: Yuanxi Jia, Johns Hopkins University
Topical Area: Nutritional Microbiology/Microbiome
Supported by: IAFNS Gut Microbiome Committee
For more information, see here.ABSTRACT
Objectives: To conduct a scoping review to map available evidence about the health impact of gut microbiota-derived metabolites in humans.
Methods: We searched PubMed and Embase for studies that assessed the health impact of gut microbiota-derived metabolites in humans. We included case-control studies, cross-sectional studies, cohort studies, and clinical trials. Any health condition was considered. Based on an initial prioritization phase informed by preliminary searching and expert input, we narrowed our scope to ten metabolites: deoxycholate or deoxycholic acid (DCA), lithocholate or lithocholic acid (LCA), glycolithocholate or glycolithocholic acid, glycodeoxycholate or glycodeoxycholic acid, tryptamine, putrescine, d-alanine, urolithins, N-acetylmannosamine, and phenylacetylglutamine. We used evidence mapping to identify evidence gaps and associations that may permit future systematic reviews. The screening was conducted in PICO Portal aided by artificial intelligence.
Results: Overall, for these 10 metabolites, we identified 352 studies with 168,072 participants. Most (326, 92.6%) were case-control studies, followed by cohort studies (14, 4.0%), clinical trials (8, 2.3%), and cross-sectional studies (6, 1.7%). Most studies assessed the following associations: DCA on hepatobiliary disorders (64 studies, 7,976 participants), colorectal cancer (19 studies, 7,461 participants), and other digestive disorders (27 studies, 2,463 participants); LCA on hepatobiliary disorders (34 studies, 4,297 participants), colorectal cancers (14 studies, 4,955 participants), and other digestive disorders (26 studies, 2,117 participants); putrescine on colorectal cancers (16 studies, 94,399 participants) and cancers excluding colorectal and hepatobiliary cancers (42 studies, 4,250 participants).
Conclusions: The association of gut microbiota-derived metabolites and human health is being examined in an increasing number of studies, most of which are case-control studies. As these metabolites hold considerable potential for elucidating microbiome-disease associations, there is a need to conduct more prospective studies including clinical trials. Moreover, systemic reviews are needed to characterize the metabolite-disease associations.
Funding Sources: Institute for the Advancement of Food and Nutrition Sciences (IAFNS)
Relationship Between Exposure to Dietary Sweetness and Body Weight-Related Outcomes in Adults: An Evidence Map: Abstract Presentation Number: PO08-20-22 Expand Presenting Author: Kelly A. Higgins, USDA, ARS
Topical Area: Dietary Patterns
Supported by: IAFNS Carbohydrates and Low- and No-Calorie Sweeteners Committees
For more information, see here.ABSTRACT
Objectives: An evidence map was conducted to characterize published research investigating dietary sweetness and body weight. The primary aim was to identify studies that investigate total dietary sweetness and body weight-related outcomes among healthy adults; the secondary aim was to map the evidence that investigates sugar, sweetener, or sweet food/beverage intake and body weight.
Methods: Using pre-registered search terms (https://osf.io/my7pb), 33,609 publications (duplicates removed) from PubMed, Cochrane Library, and Scopus were screened for inclusion. Eligible studies were cross-sectional studies, longitudinal cohort studies, case control studies, clinical trials, and systematic reviews conducted among adults (≥18 years) which investigated the associations between total dietary sweetness, sugar, sweetener (energetic or nonenergetic), or sweet food/beverage intake on body weight, body mass index, adiposity, and energy intake.
Results: A total of 824 eligible publications were identified. Two clinical trials and 5 cross-sectional studies investigated the associations between total dietary sweetness and a body weight-related outcome. An additional 630 publications were identified that investigated sugar, sweetener, or sweet food/beverage intake and body weight-related outcomes, including 225 clinical trials, 87 longitudinal cohort studies, and 298 cross-sectional studies. Ninety publications reported on dietary patterns that included sweet foods/beverages alongside other dietary components. Most studies (91%) did not measure the sweetness of the diet or individual foods consumed. Additionally, 97 systematic reviews that addressed relevant but different research questions related to sweetness exposure and body weight-related outcomes were identified.
Conclusions: While there is a breadth of evidence available from studies that investigate sugar, sweetener, and sweet food/beverage intake and body weight, there is limited evidence on the association between total dietary sweetness exposure and body weight.
Funding Sources: USDA Agricultural Research Service, Institute for the Advancement of Food and Nutrition Sciences
Quality of Popular Diets in the United States: Abstract Presentation Number: PO08-09-22 Expand Presenting Author: Zach Conrad, William & Mary
Topical Area: Dietary Patterns
Supported by: IAFNS Carbohydrates Committee
For more information, see here.ABSTRACT
Objectives: 1) Evaluate the quality of popular diets in the US, and 2) model the effect of targeted food substitutions on diet quality.
Methods: Dietary data from 34,411 adults ≥20 y were acquired from the National Health and Nutrition Examination Survey, 2005-2018. Usual dietary intake was assessed using the National Cancer Institute's usual intake methodology, and the Healthy Eating Index-2015 was used to evaluate the diet quality of eleven popular diets. A diet model was used to evaluate the effect of targeted food substitutions on diet quality.
Results: Participants that followed a pescatarian diet pattern had the highest diet quality (65.2, 95% CI: 64.0-66.4), followed by vegetarian (63.0, 62.0-63.0), very low grain (62.7, 62.2-63.3), flexible paleo (62.3, 61.1-63.4), low grain (61.2, 60.6-61.9), low-moderate grain (59.7, 59.3-60.2), omnivorous (57.8, 57.5-58.1), restricted carbohydrate (56.9, 56.6-57.3), time restricted (55.2, 54.8-55.5), moderate protein (55.0, 54.7-55.3), and high protein (51.8, 51.0-62.7). Modeled replacement of up to three daily servings of foods highest in added sugar, sodium, and saturated fat with alternative foods led to a statistically significant increase in diet quality and a decrease in energy intake for most diets (P < 0.001 for most diets).
Conclusions: Low diet quality was observed for all popular diets evaluated in this study. Modeled dietary shifts that align with recommendations to choose foods lower in added sugar, sodium, and saturated fat led to only modest improvements in diet quality but a larger reduction in energy intake. Greater efforts are needed to shift consumer perceptions away from reductionist dietary approaches that place undue emphasis on specific foods, individual macronutrients, and timing of eating, and toward healthy dietary patterns that emphasize consumption of a variety of high-quality food groups.
Funding Sources: This work was supported by the Institute for the Advancement of Food and Nutrition Sciences (IAFNS) Carbohydrate Committee. IAFNS is a nonprofit science organization that pools funding from industry collaborators and advances science through the in-kind and financial contributions from public and private sector participants. IAFNS had no role in the design, analysis, interpretation, or presentation of the data and results.
Association Between Restricted Carbohydrate Diets and Cardiometabolic Disease: Abstract Presentation Number: PO22-26-22 Expand Presenting Author: Corina Kowalski, William & Mary
Topical Area: Nutritional Epidemiology
Supported by: IAFNS Carbohydrate and Lipids Committees
For more information, see here.ABSTRACT
Objectives: This study evaluated the association between restricted carbohydrate diets and prevalent cardiometabolic disease (CMD), stratified by fat intake.
Methods: Dietary and CMD data were obtained from 19,078 participants ≥20 y in the National Health and Nutrition Examination Survey (NHANES) 1999-2018. The National Cancer Institute (NCI) methodology was used to assess usual intake of foods and nutrients.
Results: Compared to individuals that met all macronutrient recommendations, those consuming restricted carbohydrate diets ( < 45%en) were 1.123 (95% CI 1.113-1.133) times as likely to have CMD, and those consuming the recommended amount of carbohydrates only were 1.060 (1.058-1.062) times as likely to have CMD. Higher intakes of saturated and polyunsaturated fat were associated with greater prevalence of CMD in restricted and recommended carbohydrate intake groups. Higher intakes of monounsaturated fat were associated with lower prevalence of CMD among participants that met carbohydrate recommendations only.
Conclusions: Participants that consumed restricted carbohydrate diets were more likely to have CMD compared to participants that met all macronutrient recommendations, and this association was modified by fat intake. Greater efforts are needed to understand longitudinal associations between carbohydrate intake and CMD.
Funding Sources: This work was supported by the Institute for the Advancement of Food and Nutrition Sciences (IAFNS) Carbohydrate and Lipid Committees. IAFNS is a nonprofit science organization that pools funding from industry collaborators and advances science through the in-kind and financial contributions from public and private sector participants. IAFNS had no role in the design, analysis, interpretation, or presentation of the data and results.
Restricted Carbohydrate Diets High in Fat Are Associated With Increased Likelihood of Prevalent Metabolic Syndrome: Abstract Presentation Number: PO22-13-22 Expand Presenting Author: Dakota Dustin, The Ohio State University
Topical Area: Nutritional Epidemiology
Supported by: IAFNS Carbohydrate and Lipids Committees
For more information, see here.ABSTRACT
Objectives: This study evaluated the association between a restricted carbohydrate diet ( < 45% energy from carbohydrate) and metabolic syndrome stratified by fatty acid classes in a nationally representative sample of U.S adults.
Methods: Data on food and nutrient intake, and markers of metabolic syndrome, were obtained from 19,078 respondents ≥20 y in the National Health and Nutrition Examination Survey (NHANES) 1999-2018. The National Cancer Institute's usual intake methodology was used to evaluate the associations between usual dietary intake and prevalent metabolic syndrome.
Results: Compared to individuals that met all AMDR macronutrient recommendations, the odds of having metabolic syndrome were 1.085 (95%CI: 1.077-1.094) times higher among those that consumed a restricted carbohydrate diet (P < 0.001) and 1.115 (1.153-1.156) times higher for those that met only current recommendations for total carbohydrates (P < 0.001). Higher fat intake, regardless of class, was associated with increased likelihood of metabolic syndrome among individuals that consumed restricted carbohydrate diets but not among individuals that met current carbohydrate recommendations.
Conclusions: The likelihood of prevalent metabolic syndrome was moderately higher (8.5%) among individuals that consumed restricted carbohydrate diets compared to individuals that met all macronutrient recommendations. High intake of fat of any class was associated with increased likelihood of metabolic syndrome in those consuming a restricted carbohydrate diet.
Funding Sources: This work was supported by the Institute for the Advancement of Food and Nutrition Sciences (IAFNS) Carbohydrate and Lipid Committees. IAFNS is a nonprofit science organization that pools funding from industry collaborators and advances science through the in-kind and financial contributions from public and private sector participants. IAFNS had no role in the design, analysis, interpretation, or presentation of the data and results.
Associations Between Essential Amino Acids and Functional Health Outcomes in Older Adults: Analysis of the National Health and Nutrition Examination Survey, 2001-2018:Abstract Presentation Number: PO22-09-22 Expand Abstract Topical Area: Nutritional Epidemiology, FSU Metabolic Kitchen & Diet Assessment Center
Presenting Author: Susan Cheung
Supported by: IAFNS Protein Committee
For more information, see here.ABSTRACT:
Objectives: Little is known about the relationships between habitual essential amino acid (EAA) intake and functional health in older US adults. This cross-sectional study investigates associations between usual EAA intakes and body composition, muscle strength, and physical function in US adults ≥ 65 y.
Methods: The Food and Nutrient Database for Dietary Studies (FNDDS) 2001-2018 was linked to USDA FoodData Central to access existing EAA composition data for FNDDS ingredients. FNDDS ingredients without existing EAA data were matched to similar ingredient codes with available EAA data. Usual intakes of EAA, leucine, lysine, and sulfur-containing AAs (SAA; methionine + cysteine) from NHANES 2001-2018 were calculated as relative [mg/kg ideal body weight (IBW)/d] and absolute (g/d) intakes for individuals ≥ 65 y (n=10,843). Dependent variables were muscle strength measured by isometric grip test, BMI, waist circumference (WC), DXA-measured appendicular lean mass and whole-body fat mass, and self-reported physical function. Regression analyses were used to determine covariate-adjusted relationships between EAA, leucine, lysine, and SAA intake and functional health outcomes. P < 0.0013 was considered significant.
Results: Absolute and relative EAA, leucine, lysine, and SAA intakes were not associated with muscle strength or self-reported physical function in males or females or with body composition in males. Absolute EAA intakes (per g) were associated with WC in females (β ± SEM, 2.1 ± 0.6 cm, P = 0.0007). Absolute lysine intakes (per g) were associated with BMI (3.0 ± 0.7 kg/m2, P < 0.0001) and WC (7.0 ± 1.7 cm, P = 0.0001) in females. Relative EAA, leucine, and lysine intakes (per mg/kg IBW) were associated with BMI (0.07 ± 0.02, 0.26 ± 0.07, and 0.25 ± 0.04 kg/m2, respectively; P ≤ 0.0004 for all) and WC (0.18 ± 0.03, 0.81 ± 0.17, and 0.64 ± 0.10 cm, respectively; P < 0.0001 for all) in females. Relative lysine intakes (per mg/kg IBW) were associated with whole body fat mass (0.24 ± 0.07 kg, P = 0.0006) in females.
Conclusions: EAA intakes, particularly lysine, were positively associated with measures of adiposity in women ≥ 65 y. Investigating sources of lysine intake may provide insight about which foods or food groups are driving this relationship.
Funding Sources: IAFNS Protein Committee, USAMRDC, DoD Center Alliance for Nutrition and Dietary Supplements Research
Amino Acid Intake and Conformance With the Dietary Reference Intakes in the United States: Analysis of the National Health and Nutrition Examination Survey, 2001-2018: Abstract Presentation Number: PO22-06-22 Expand Abstract Topical Area: Nutritional Epidemiology
Presenting Author: Claire Berryman, Florida State University
Supported by: IAFNS Protein Committee
For more information, see here. ABSTRACT
Objectives: The lack of complete amino acid composition data in food composition databases has made determining population-wide amino acid intake difficult. This cross-sectional study characterizes habitual intakes of each amino acid and adherence to dietary requirements for each essential amino acid (EAA) by age, gender, and race/ethnicity in the US population.Methods: Food and Nutrient Database for Dietary Studies ingredient codes with missing amino acid composition data were matched to similar ingredients with available data, so that amino acid composition could be determined for virtually 100% of foods reported in What We Eat in America, the dietary intake assessment component of NHANES. Amino acid intakes during 2-y cycles of NHANES 2001-2018 (n = 84,629; ≥ 2y) were calculated as relative [mg/kg of ideal body weight (IBW)/d] and absolute (g/d) intakes. Data from NHANES 2011-2018 were used to determine the percentage of the population consuming less than the Dietary Reference Intakes for each EAA by age, sex, and race/ethnicity.
Results: Relative intakes of EAAs were greatest in those 2-3 y (females: 1552 ± 9 and males: 1659 ± 9 mg/kg IBW/d) and lowest in those ≥ 80 y (females: 446 ± 2 and males: 461 ± 3 mg/kg IBW/d). Absolute intakes of EAAs were greatest in those 31-50 y (females: 31.4 ± 0.1 and males: 45.5 ± 0.1 g/d) and lowest in those 2-3 y (females: 22.4 ± 0.1 and males: 26.0 ± 0.1 g/d). In individuals 2-18 y and ≥ 19 y, relative intakes of EAAs were lowest in the NHB population (860 ± 16 and 505 ± 5 mg/kg IBW/d, respectively) and highest in the Asian population (994 ± 35 and 580 ± 7 mg/kg IBW/d, respectively). Less than 1% of individuals ≥ 19 y were not meeting the Estimated Average Requirements for each EAA.
Conclusions: Individual amino acid intakes in the US population exceed recommended minimum population requirements. Future studies can use the method described here to quantify habitual amino acid intake and examine relationships with health and disease.
Funding Sources: Institute for the Advancement of Food and Nutrition Sciences (IAFNS) Protein Committee, US Army Medical Research and Development Command, and the Department of Defense Center Alliance for Nutrition and Dietary Supplements Research.
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