Genetic differences have been shown to explain why blood LDL-cholesterol increases in many people fed dairy fat, but in others this results in a neutral or decreased response LDL response. Likewise, specific genetic modifiers have been shown to predict why cholesterol-lowering plant sterols are highly effective in many people, but not in others. Customizing dietary guidance to those likely to realize benefit is paramount to improving efficacy of dietary recommendations. The aim of this study is to develop a model that predicts the effects of lipid-modulating dietary components using genetic multi-SNP algorithms.
Institution: University of Manitoba
Principal Investigator: Peter Jones, PhD
Year Awarded: 2017
Read more: A Combination of Single Nucleotide Polymorphisms is Associated with the Interindividual Variability in the Blood Lipid Response to Dietary Fatty Acid Consumption in a Randomized Clinical Trial
Learn more about the IAFNS Dietary Lipids Committee.