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Fluid-Electrolyte and Renal Indices of Hydration During Eleven Days of Controlled Caffeine Consumption

After identifying critical gaps in caffeine research, this study examined the effects of tolerance and withdrawal from caffeine on hydration status in subjects who are regular users of caffeine. The findings were published in the International Journal of Sport Nutrition and Exercise Metabolism (2005;15:252-265).

Read more about Fluid-Electrolyte and Renal Indices of Hydration During Eleven Days of Controlled Caffeine Consumption

Kinetic and Mechanistic Data for a Human Physiologically Bases Pharmacokinetic (PBPK) Model for Acrylamide

Despite gaps and limitations to the database, model parameters have been estimated to provide a relatively consistent description of the kinetics of acrylamide and glycidamide using a single set of values (with minor adjustments in some cases). This review, published in Advances in Experimental Medicine and Biology (2005;561:117-125), discusses the PBPK model for acrylamide.

Read more about Kinetic and Mechanistic Data for a Human Physiologically Bases Pharmacokinetic (PBPK) Model for Acrylamide

Human Exposure and Internal Dose Assessments of Acrylamide in Food

This review, published in Food and Chemical Toxicology (2005;43:365-410), provides a framework contributing to the risk assessment of acrylamide in food. It is based on the outcome of the ILSI Europe FOSIE process, a risk assessment framework for chemicals in foods and adds to the overall framework by focusing especially on exposure assessment and internal dose assessment of acrylamide in food.

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