RFP Issued: Systematic Review of Low-Calorie Sweeteners and Glycemic Response

Globally, dietary guidance recommends reducing added and total sugars in the diet to reduce calories and chronic disease. When substituted for sugars, low-calorie sweeteners (LCS) present a mechanism for reducing added sugars intake and potentially calories, while providing sweet taste. The IAFNS LCS committee wishes to sponsor a systematic review of randomized controlled trials (RCTs) and prospective cohort studies conducted in adults, that examines the relation between LCS on glycemia response and/or control. If this review finds enough evidence to allow a quantitative evaluation with meta-analyses, a follow-up project will be considered. Click here to view the full RFP.

Deadline: Proposals must be received by April 16, 2018.

Review Objectives:

  1. Summarize the evidence on the potential relationship between the intake of low-calorie sweeteners and glycemic response and control in various populations, and potentially in a second phase project, conducting meta-analyses as appropriate;
  2. Evaluate the strength of the existing evidence; and if an effect is found, if it is physiologically meaningful;
  3. Identify where research gaps exist; and
  4. Make all studies included in the review publicly available on the Agency for Healthcare Research Quality’s Systematic Review Data Repository website for ease of future analyses and for transparency of the process.

For questions or more information, contact Marie Latulippe (mlatulippe@iafnsconnect.wpengine.com) or Courtney McComber (cmccomber@iafnsconnect.wpengine.com).