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Speakers:
Nancy Bontempo, PhD, Mondelez International
Delia Murphy, IAFNS

Background:
This presentation will provide an overview of the results of two IAFNS sponsored research projects: “Correlation of surrogate bacteria and Salmonellae for validation of spice/herb pathogen reduction processes” and “Protocol and surrogate validation for the inactivation of Salmonella on whole black peppercorns and cumin seeds.”

The projects used four spices, oregano, onion powder, whole black peppercorns, and whole cumin seeds, and focused on evaluating the usefulness of surrogate bacteria for validation of irradiation as a decontamination processes, and developing validated protocols for inactivation of Salmonella using ethylene oxide fumigation and dry steam (vacuum-assisted) treatment. The American Spice Trade Association provided an unrestricted grant to help fund these research projects.

This work is supported by the IAFNS Food Microbiology Committee.

[post_title] => ASTA Annual Meeting [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => asta-annual-meeting [to_ping] => [pinged] => [post_modified] => 2017-04-28 13:59:05 [post_modified_gmt] => 2017-04-28 13:59:05 [post_content_filtered] => [post_parent] => 0 [guid] => https://iafnsconnect.wpengine.com/?post_type=event&p=2421 [menu_order] => 0 [post_type] => event [post_mime_type] => [comment_count] => 0 [filter] => raw ) [2] => WP_Post Object ( [ID] => 2388 [post_author] => 343 [post_date] => 2017-03-24 19:37:55 [post_date_gmt] => 2017-03-24 19:37:55 [post_content] => Official Program About this session Expand

While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews", as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., "Effects of caffeine on human health", there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos Expand Welcome
Alison Kretser, MS, RD, IAFNS The Caffeine Landscape - framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 - 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video

Results of Specific Health Endpoints- Scientific Advisory Board Members

  • Harris Lieberman, US Army - Behavior - Video 
  • Charles O'Brien, University of Pennsylvania - Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma - Reproductive & Developmental Toxicity - Video 
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine- Cardiovascular - Video 
  • Connie Weaver, PhD, Purdue University - Bone & Calcium - Video 
  • Milton Tenenbein, MD, University of Manitoba - Acute & Pharmacokinetics - Video 
Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of IAFNS (Oversight Committee) Overall Conclusions - presented by Daniele Wikoff
Full session playlist  CoffeeBambooSmall

See IAFNS's other sessions at Experimental Biology 2017:

Full Schedule Learn more [post_title] => Conducting a Systematic Review for a Global Audience: Challenges in Merging Nutrition and Toxicological Evidence for a Safety Assessment of Caffeine [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => experimental-biology-2017-2 [to_ping] => [pinged] => [post_modified] => 2021-02-09 16:44:05 [post_modified_gmt] => 2021-02-09 16:44:05 [post_content_filtered] => [post_parent] => 0 [guid] => https://iafnsconnect.wpengine.com/?post_type=event&p=2388 [menu_order] => 0 [post_type] => event [post_mime_type] => [comment_count] => 0 [filter] => raw ) [3] => WP_Post Object ( [ID] => 2386 [post_author] => 343 [post_date] => 2017-03-24 17:02:46 [post_date_gmt] => 2017-03-24 17:02:46 [post_content] => Conducting a Systematic Review for a Global Audience: Challenges in Merging Nutrition and Toxicological Evidence for a Safety Assessment of Caffeine
Saturday, 22 April 2017
8:30AM - 12:30PM
Ballroom S100BC
Speakers: Dennis Keefe, FDA; Harris Lieberman, USARIEM; Esther Myers, EF Myers Consulting; Charles O'Brien, University of Pennsylvania; Jennifer Peck, University of Oklahoma; Milton Tenenbein, University of Manitoba; Connie Weaver, Purdue University; Daniele Wikoff, ToxStrategies
Supported by the Caffeine Working Group
Session Info & Videos The Changing Brain: How Brain Plasticity, Exercise and Nutrition Affect Function and Cognition
Saturday, 22 April 2017
3:00PM - 5:00PM,
Ballroom S100BC
  • Neurogensis and brain plasticity in the adult brain - Henriette van Praag, National Institute on Aging;
  • The Relation of Exercise, fitness, & Adiposity to Cognitive and Brain Health - Charles Hillman, University of Illinois - Video
  • Neuroinflammatory Processes in Cognitive Disorders - Sophie Laye, Universite Bordeaux - Video
  • Exercise, Nutrition and Brain Funciton: What are the steps toward dietary and physical activity Recommendations? - Mary Ann Johnson, University of Georgia - Video
  • Panel Discussion - Video
Utility of Predictive Modeling for Nutrition Research, Clinical Interventions and Public Health
Sunday, 23 April 2017
8:30AM- 10:30AM
S105BCD
Speakers:
  • Intro to Predictive Modeling: From Linear Regression Models to Mechanistic Mathematical Modeling - David Allison, University of Alabama at Birmingham - Video;
  • Use of Predictive Modeling in the Design of Clinical Studies Kevin Hall, NIDDK - Video;
  • Application of Predictive Modeling in Weight Loss Counseling -  Corby Martin, Pennington Biomedical Research Center - Video;
  • Application of Predictive Modeling in Personalized Nutrition - Ben van Ommen, TNO - Video;
  • Utility of PRedictive Modeling for Public Health Obesity Policies - Emily Dhurandhar, Texas Tech University - Video;
  • Summary and Wrap-Up - Diana Thomas, West Point - Video
    Supported by the Protein Committee
  • Full session playlist
Learning Lab: How to Access and Use a Fiber and Health Outcomes Database for Researchers and Policymakers
Tuesday, 25 April 2017
11:00AM - 12:30PM
S105AB
Speakers: Kara Livingston, Tufts University; Caleigh Sawicki, Tufts University
Supported by the Carbohydrate Committee Posters
Sources of dietary folate/folic acid in women of different races in the United States between 2009 and 2012: What is the role of fortified and enriched products?
PDF
Abstract Number: 6707
Poster Board Number C88
Presenter: Ray DeVirgiliis, George Washington University
Monday, 24 April
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