A metal dietary exposure screening tool (MDEST) was previously developed by the IAFNS Food and Chemical Safety Committee to assist with rapid risk assessment of metals in foods. The tool allows data input for amounts of lead, cadmium, arsenic, chromium, and mercury and generates average exposure levels that could aid in risk management and decision-making. This project will update the MDEST with new exposure limits for select heavy metals and integrate the new levels with updated consumption data to generate new screening-level exposure estimates.
A Reassessment of Regulatory Reference Values and Background Exposure Levels for Heavy Metals in the Human Diet. Candace Wong and Neal Saab. 2020.
Poster presentation at the 2020 Society of Toxicology (SOT) Annual Meeting
This project focuses on the application of read across approaches for food related chemicals in ToxCast to understand their potential use in food safety assessment. This work was presented at the 2017 American Society for Cellular and Computational Toxicology Annual Meeting.
The ToxCast program has generated a lot of in vitro high throughput screening (HTS) data, however, interpretation and use of the ToxCast data such as for safety assessment of food related compounds remains undetermined. The IAFNS 2016 Summer Fellow conducted case studies using the Risk21 approach to better understand the ToxCast data for food-relevant chemicals and its potential use in chemical safety assessments by comparison with traditional toxicology studies.
"An Approach to Standardize the Concepts of “Lose Dose and Nonmonotonic Dose Response in Toxicological Research and Regulatory Science" - presented at:
"Toxicology and Risk Assessment of Chemical Mixtures." presented at the following meetings:
- EuroTox 2015
- IAFP 2015
- EuroTox 2014
- SOT 2015
- EFSA Scientific Colloquium N°21 on "Harmonisation of human ecological risk assessment of combined exposure to multiple chemicals" - A summary of this colloquium can be found here.
- SOT 2014 - Mansi Krishan, PhD received the Food Safety Frank C. Lu Student Award at the 2014 SOT Annual Meeting. View Poster
A video interview with Dr. Krishan can be viewed here.
Publication: Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program
- SOT 2014 - "Evaluation of Food-Relevant Chemicals in ToxCast Phase II"
EPA Second ToxCast Data Summit, September 2014 - Agnes Karmaus(2012 Summer Fellow) presented a poster of her work "Bioactivity of Food-Relevant Chemicals in ToxCast" . The abstract is available here.
- IUFoST 2014 - "Evaluation of Food-Relevant Chemicals in ToxCast"
- IAFP 2014 - "21st Century Chemical Food Safety Assessment Challenges"
SOT 2013 - "Evaluation of Food-Relevant Chemicals in ToxCast Phase II"
Read a blog from Dr. Karmaus about the fellowship here
A video inteview with Dr. Karmaus can be viewed here