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							Official Program
					
			About this session
							Expand
		

While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews", as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., "Effects of caffeine on human health", there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos Expand Welcome
Alison Kretser, MS, RD, IAFNS The Caffeine Landscape - framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 - 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video

Results of Specific Health Endpoints- Scientific Advisory Board Members

  • Harris Lieberman, US Army - Behavior - Video 
  • Charles O'Brien, University of Pennsylvania - Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma - Reproductive & Developmental Toxicity - Video 
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine- Cardiovascular - Video 
  • Connie Weaver, PhD, Purdue University - Bone & Calcium - Video 
  • Milton Tenenbein, MD, University of Manitoba - Acute & Pharmacokinetics - Video 
Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of IAFNS (Oversight Committee) Overall Conclusions - presented by Daniele Wikoff
Full session playlist  CoffeeBambooSmall

See IAFNS's other sessions at Experimental Biology 2017:

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Saturday, 22 April 2017
8:30AM - 12:30PM
Ballroom S100BC
Speakers: Dennis Keefe, FDA; Harris Lieberman, USARIEM; Esther Myers, EF Myers Consulting; Charles O'Brien, University of Pennsylvania; Jennifer Peck, University of Oklahoma; Milton Tenenbein, University of Manitoba; Connie Weaver, Purdue University; Daniele Wikoff, ToxStrategies
Supported by the Caffeine Working Group
Session Info & Videos The Changing Brain: How Brain Plasticity, Exercise and Nutrition Affect Function and Cognition
Saturday, 22 April 2017
3:00PM - 5:00PM,
Ballroom S100BC
  • Neurogensis and brain plasticity in the adult brain - Henriette van Praag, National Institute on Aging;
  • The Relation of Exercise, fitness, & Adiposity to Cognitive and Brain Health - Charles Hillman, University of Illinois - Video
  • Neuroinflammatory Processes in Cognitive Disorders - Sophie Laye, Universite Bordeaux - Video
  • Exercise, Nutrition and Brain Funciton: What are the steps toward dietary and physical activity Recommendations? - Mary Ann Johnson, University of Georgia - Video
  • Panel Discussion - Video
Utility of Predictive Modeling for Nutrition Research, Clinical Interventions and Public Health
Sunday, 23 April 2017
8:30AM- 10:30AM
S105BCD
Speakers:
  • Intro to Predictive Modeling: From Linear Regression Models to Mechanistic Mathematical Modeling - David Allison, University of Alabama at Birmingham - Video;
  • Use of Predictive Modeling in the Design of Clinical Studies Kevin Hall, NIDDK - Video;
  • Application of Predictive Modeling in Weight Loss Counseling -  Corby Martin, Pennington Biomedical Research Center - Video;
  • Application of Predictive Modeling in Personalized Nutrition - Ben van Ommen, TNO - Video;
  • Utility of PRedictive Modeling for Public Health Obesity Policies - Emily Dhurandhar, Texas Tech University - Video;
  • Summary and Wrap-Up - Diana Thomas, West Point - Video
    Supported by the Protein Committee
  • Full session playlist
Learning Lab: How to Access and Use a Fiber and Health Outcomes Database for Researchers and Policymakers
Tuesday, 25 April 2017
11:00AM - 12:30PM
S105AB
Speakers: Kara Livingston, Tufts University; Caleigh Sawicki, Tufts University
Supported by the Carbohydrate Committee Posters
Sources of dietary folate/folic acid in women of different races in the United States between 2009 and 2012: What is the role of fortified and enriched products?
PDF
Abstract Number: 6707
Poster Board Number C88
Presenter: Ray DeVirgiliis, George Washington University
Monday, 24 April
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Co-hosted by U.S. Food and Drug Administration, Center for Food Safety & Applied Nutrition (CFSAN) and the IAFNS Technical Committee on Food & Chemical Safety

This workshop will bring together scientists from government, academia and industry to discuss the advances in testing strategies to reduce animal testing and the need for the development of a standardized approach for use of these alternative methodologies in food safety assessment.

Workshop Proceedings:

State of the Science on Alternatives to Animal Testing and Integration of Testing Strategies for Food Safety Assessments

Read the Proceedings Registration Expand

There is no fee to attend the workshop but, registration is required by Tuesday, February 21. Please register for the workshop using this link: Workshop Registration

Webcast Registration
Register for webcast here: webcast registration
Webcast participants can submit questions online during the event. These will be answered as time allows. Agenda Expand

8:30-8:40 am: Welcome Suzanne Fitzpatrick, FDA Mansi Krishan, IAFNS

8:40-8:55am
Introductory Remarks
Dennis Keefe, FDA
Heidi Bialk, IAFNS Member Scientist 8:55-9:35am
Integrated Testing Strategies in Food Safety
Alan Boobis, Imperial College London [30 mins + 10 mins Q & A] 9:35-10:15am
State of the Science on High Through-Put Screening (HTS): Food Safety Perspective
Nadine Bewry, FDA 10:30-11:10am
Case Studies to Describe the Limitations of Using HTS data in Food Safety Assessment
Rebecca Clewell, ScitoVation 11:10 -11:50am
Identify and Translate Learnings from On-Going Assay Validation Efforts into Standard HTS Testing Practices
Richard Judson, EPA 12:50- 1:30pm
Read Across Approaches: Chemical Structure and Bioactivity Profiling Applicable to Food Safety
Grace Patlewicz, EPA 1:30-2:10pm
FDA Perspective on Read Across Approaches
Tim Adams, FDA 2:10-2:50 pm
Organ on a Chip Technology
Daniel Levner, Emulate 3:05- 4:30pm
Panel Discussion Moderator: Suzanne Fitzpatrick, FDA Panelists:
All speakers, Thomas Hartung, Johns Hopkins University and Katya Tsaioun, Johns Hopkins University 4:30-4:40pm
Concluding Remarks
Suzanne Fitzpatrick
FDA Mansi Krishan, IAFNS Videos Expand

A video of the workshop can be found on the FDA YouTube channel

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While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews", as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., "Effects of caffeine on human health", there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos Expand Welcome
Alison Kretser, MS, RD, IAFNS The Caffeine Landscape - framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 - 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video

Results of Specific Health Endpoints- Scientific Advisory Board Members

  • Harris Lieberman, US Army - Behavior - Video 
  • Charles O'Brien, University of Pennsylvania - Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma - Reproductive & Developmental Toxicity - Video 
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine- Cardiovascular - Video 
  • Connie Weaver, PhD, Purdue University - Bone & Calcium - Video 
  • Milton Tenenbein, MD, University of Manitoba - Acute & Pharmacokinetics - Video 
Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of IAFNS (Oversight Committee) Overall Conclusions - presented by Daniele Wikoff
Full session playlist  CoffeeBambooSmall

See IAFNS's other sessions at Experimental Biology 2017:

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Nutrition is the American Society for Nutrition's inaugural flagship meeting. IAFNS is supporting several sessions at Nutrition 2018:

Videos of the NUTRITION 2018 scientific sessions are now available! Click on a session to view the videos.

"The Future of Taste and Health - Converging Areas of Science to Promote Healthy Dietary Patterns" Expand

Saturday, June 9th, 2018. Supported by the IAFNS Taste and Diet Working Group.

Watch the full session

  • Lay of the Taste Land - Taste Evolution, Mechanisms, and Functions
    Gary Beauchamp, PhD, Monell Chemical Senses Center
  • Non-Mechanistic Determinants of the Taste Experience: How Culture, Environment, and Habit Influence Taste
    John Hayes, PhD, The Pennsylvania State University
  • Sensory Properties of Food and Implications for Food Choice
    Chris Simons, PhD, Ohio State University
  • Improving the Nutritional Profile of Products While Maintaining Taste: Industry Perspective
    Jane Leland, PhD, Consultant
  • Modifying Consumer Preference to Improve Dietary Choices
    Debra Zellner, PhD, Montclair State University
  • What Do We Know About Taste and Food Choice?
    Naomi Fukagawa, PhD, USDA ARS Beltsville Human Nutrition Research Center
"ASN/Canadian Nutrition Society Session: Ensuring Trust in Nutrition Science" Expand

Saturday, June 9th, 2018. Supported by the Scientific Integrity Consortium. IAFNS is an active member of the Consortium.

Watch the full session

  • Session Chair
    James House, PhD, University of Manitoba
  • Best Practices in Nutrition Science to Earn and Keep the Public's Trust
    Patrick Stover, PhD, Texas A&M
  • Report from the Scientific Integrity Consortium: Principles & Best Practices
    Catherine Woteki, PhD, Iowa State University
  • Using Risk of Bias Domains to Identify Opportunities for Improvement in Food- and Nutrition-related Research: An Evaluation of Research Type and Design, Year of Publication, and Source of Funding
    Esther Myers, PhD, RD, FADA, EF Myers Consulting, Inc. This talk was supported by the IAFNS Assembly on Scientific Integrity.
"Best Practices in Measuring and Reporting Blood Fatty Acids in Human Nutrition Studies" Expand

Monday, June 11th, 2018. Supported by the IAFNS Dietary Lipids Committee.

Watch the full session

  • Overview: The Need for Guidelines and the Process
    J. Thomas Brenna, PhD, University of Texas at Austin
  • Study Design and Interpretation
    Melanie Plourde, PhD, Université de Sherbrooke
  • Laboratory Analysis and Reporting
    Peter Jones, PhD, University of Manitoba
"The Sodium Conundrum" Expand

Tuesday, June 12th, 2018. Supported by the IAFNS Sodium Committee.

Watch the full session.

  • Introduction and Session Overview
    Moderator/Session Chair: Christine Taylor, PhD, FDA (retired)
  • Relationship of Sodium and Potassium to Chronic Disease: AHRQ Systematic Review
    Janet de Jesus, MS, RD, HHS, Office of Disease Prevention and Health Promotion
  • Developing Guidance for Inclusion of Chronic Disease Endpoints in DRIs: Implication for Sodium and Potassium
    Marian Neuhouser, PhD, RD, Fred Hutchinson Cancer Research Center
  • Overview of FDA Sodium Reduction Guidance
    Christine Taylor, PhD, FDA (retired)
  • Progress in Sodium Reduction by the Food Industry
    Joshua Anthony, PhD, MBA, The Campbell Soup Company
"Neurocognition: The First 1000 Days" Expand

This symposium aims to highlight recent scientific discoveries addressing how availability of distinct nutrients, along with genetic differences in nutrient metabolism capacity, affect the elaborate cellular and molecular processes that take place during brain development, focusing on basic science and clinically-­‐relevant scientific advances.

Symposium Chair:
Christopher Lynch, PhD, NIH, Director, Office of Nutrition Research
Chief, Nutrition Research Branch

Speakers:

Development of the Brain During the First 1000 Days of Life:
Lisa Freund, PhD, Eunice Kennedy Shriver National Institute Child Health and Human Development Iron: A Key Nutrient and a Paradigm of Nutrient-Brain Interactions:
Michael Georgieff, MD, University of Minnesota The Relation Between Maternal Genotype, Lipid Intake and Metabolism, and Infant and Toddler Cognitive Performance:
Carol Cheatham, PhD, UNC Chapel Hill Nutrition Research Institute The Impact of Maternal Choline Metabolism on Brain Development:
Steven Zeisel, MD, PhD, UNC Chapel Hill Nutrition Research Institute

 

 

More information about Nutrition 2018 is available here.

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