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							Official Program
					
			About this session
							Expand
		

While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews", as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., "Effects of caffeine on human health", there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos Expand Welcome
Alison Kretser, MS, RD, IAFNS The Caffeine Landscape - framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 - 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video

Results of Specific Health Endpoints- Scientific Advisory Board Members

  • Harris Lieberman, US Army - Behavior - Video 
  • Charles O'Brien, University of Pennsylvania - Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma - Reproductive & Developmental Toxicity - Video 
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine- Cardiovascular - Video 
  • Connie Weaver, PhD, Purdue University - Bone & Calcium - Video 
  • Milton Tenenbein, MD, University of Manitoba - Acute & Pharmacokinetics - Video 
Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of IAFNS (Oversight Committee) Overall Conclusions - presented by Daniele Wikoff
Full session playlist  CoffeeBambooSmall

See IAFNS's other sessions at Experimental Biology 2017:

Full Schedule Learn more [post_title] => Conducting a Systematic Review for a Global Audience: Challenges in Merging Nutrition and Toxicological Evidence for a Safety Assessment of Caffeine [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => experimental-biology-2017-2 [to_ping] => [pinged] => [post_modified] => 2021-02-09 16:44:05 [post_modified_gmt] => 2021-02-09 16:44:05 [post_content_filtered] => [post_parent] => 0 [guid] => https://iafnsconnect.wpengine.com/?post_type=event&p=2388 [menu_order] => 0 [post_type] => event [post_mime_type] => [comment_count] => 0 [filter] => raw ) [1] => WP_Post Object ( [ID] => 2386 [post_author] => 343 [post_date] => 2017-03-24 17:02:46 [post_date_gmt] => 2017-03-24 17:02:46 [post_content] => Conducting a Systematic Review for a Global Audience: Challenges in Merging Nutrition and Toxicological Evidence for a Safety Assessment of Caffeine
Saturday, 22 April 2017
8:30AM - 12:30PM
Ballroom S100BC
Speakers: Dennis Keefe, FDA; Harris Lieberman, USARIEM; Esther Myers, EF Myers Consulting; Charles O'Brien, University of Pennsylvania; Jennifer Peck, University of Oklahoma; Milton Tenenbein, University of Manitoba; Connie Weaver, Purdue University; Daniele Wikoff, ToxStrategies
Supported by the Caffeine Working Group
Session Info & Videos The Changing Brain: How Brain Plasticity, Exercise and Nutrition Affect Function and Cognition
Saturday, 22 April 2017
3:00PM - 5:00PM,
Ballroom S100BC
  • Neurogensis and brain plasticity in the adult brain - Henriette van Praag, National Institute on Aging;
  • The Relation of Exercise, fitness, & Adiposity to Cognitive and Brain Health - Charles Hillman, University of Illinois - Video
  • Neuroinflammatory Processes in Cognitive Disorders - Sophie Laye, Universite Bordeaux - Video
  • Exercise, Nutrition and Brain Funciton: What are the steps toward dietary and physical activity Recommendations? - Mary Ann Johnson, University of Georgia - Video
  • Panel Discussion - Video
Utility of Predictive Modeling for Nutrition Research, Clinical Interventions and Public Health
Sunday, 23 April 2017
8:30AM- 10:30AM
S105BCD
Speakers:
  • Intro to Predictive Modeling: From Linear Regression Models to Mechanistic Mathematical Modeling - David Allison, University of Alabama at Birmingham - Video;
  • Use of Predictive Modeling in the Design of Clinical Studies Kevin Hall, NIDDK - Video;
  • Application of Predictive Modeling in Weight Loss Counseling -  Corby Martin, Pennington Biomedical Research Center - Video;
  • Application of Predictive Modeling in Personalized Nutrition - Ben van Ommen, TNO - Video;
  • Utility of PRedictive Modeling for Public Health Obesity Policies - Emily Dhurandhar, Texas Tech University - Video;
  • Summary and Wrap-Up - Diana Thomas, West Point - Video
    Supported by the Protein Committee
  • Full session playlist
Learning Lab: How to Access and Use a Fiber and Health Outcomes Database for Researchers and Policymakers
Tuesday, 25 April 2017
11:00AM - 12:30PM
S105AB
Speakers: Kara Livingston, Tufts University; Caleigh Sawicki, Tufts University
Supported by the Carbohydrate Committee Posters
Sources of dietary folate/folic acid in women of different races in the United States between 2009 and 2012: What is the role of fortified and enriched products?
PDF
Abstract Number: 6707
Poster Board Number C88
Presenter: Ray DeVirgiliis, George Washington University
Monday, 24 April
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Co-hosted by U.S. Food and Drug Administration, Center for Food Safety & Applied Nutrition (CFSAN) and the IAFNS Technical Committee on Food & Chemical Safety

This workshop will bring together scientists from government, academia and industry to discuss the advances in testing strategies to reduce animal testing and the need for the development of a standardized approach for use of these alternative methodologies in food safety assessment.

Workshop Proceedings:

State of the Science on Alternatives to Animal Testing and Integration of Testing Strategies for Food Safety Assessments

Read the Proceedings Registration Expand

There is no fee to attend the workshop but, registration is required by Tuesday, February 21. Please register for the workshop using this link: Workshop Registration

Webcast Registration
Register for webcast here: webcast registration
Webcast participants can submit questions online during the event. These will be answered as time allows. Agenda Expand

8:30-8:40 am: Welcome Suzanne Fitzpatrick, FDA Mansi Krishan, IAFNS

8:40-8:55am
Introductory Remarks
Dennis Keefe, FDA
Heidi Bialk, IAFNS Member Scientist 8:55-9:35am
Integrated Testing Strategies in Food Safety
Alan Boobis, Imperial College London [30 mins + 10 mins Q & A] 9:35-10:15am
State of the Science on High Through-Put Screening (HTS): Food Safety Perspective
Nadine Bewry, FDA 10:30-11:10am
Case Studies to Describe the Limitations of Using HTS data in Food Safety Assessment
Rebecca Clewell, ScitoVation 11:10 -11:50am
Identify and Translate Learnings from On-Going Assay Validation Efforts into Standard HTS Testing Practices
Richard Judson, EPA 12:50- 1:30pm
Read Across Approaches: Chemical Structure and Bioactivity Profiling Applicable to Food Safety
Grace Patlewicz, EPA 1:30-2:10pm
FDA Perspective on Read Across Approaches
Tim Adams, FDA 2:10-2:50 pm
Organ on a Chip Technology
Daniel Levner, Emulate 3:05- 4:30pm
Panel Discussion Moderator: Suzanne Fitzpatrick, FDA Panelists:
All speakers, Thomas Hartung, Johns Hopkins University and Katya Tsaioun, Johns Hopkins University 4:30-4:40pm
Concluding Remarks
Suzanne Fitzpatrick
FDA Mansi Krishan, IAFNS Videos Expand

A video of the workshop can be found on the FDA YouTube channel

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While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews", as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., "Effects of caffeine on human health", there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos Expand Welcome
Alison Kretser, MS, RD, IAFNS The Caffeine Landscape - framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 - 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video

Results of Specific Health Endpoints- Scientific Advisory Board Members

  • Harris Lieberman, US Army - Behavior - Video 
  • Charles O'Brien, University of Pennsylvania - Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma - Reproductive & Developmental Toxicity - Video 
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine- Cardiovascular - Video 
  • Connie Weaver, PhD, Purdue University - Bone & Calcium - Video 
  • Milton Tenenbein, MD, University of Manitoba - Acute & Pharmacokinetics - Video 
Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of IAFNS (Oversight Committee) Overall Conclusions - presented by Daniele Wikoff
Full session playlist  CoffeeBambooSmall

See IAFNS's other sessions at Experimental Biology 2017:

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2019

Development of a Human Whole Stool Reference Material Certified for its Metabolomic Components: A Scoping Workshop

Gaithersburg, MD, USA

The IAFNS Gut Microbiome Committee is working towards developing a set of Human Whole Stool Reference Materials in collaboration with the National Institute of Standards and Technology (NIST). The goal is to quantify gut microbial metabolites in the material that have been linked to diet and health.

Read more about Development of a Human Whole Stool Reference Material Certified for its Metabolomic Components: A Scoping Workshop

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Each year, the International Association for Food Protection hosts an Annual Meeting, providing attendees with information on current and emerging food safety issues, the latest science, innovative solutions to new and recurring problems, and the opportunity to network with thousands of food safety professionals from around the globe.

IAFNS is supporting three sessions, a roundtable event and three posters at the 2019 IAFP Annual Meeting.

Scientific Sessions:

Managing Large Multidisciplinary/Multi-Institutional Food Safety Projects - Effectively, Impactfully, and with Integrity Expand

Monday, July 22, 2019 | 1:30 - 5:15 PM | Ballroom D

Food safety is a complex and multidisciplinary challenge. Therefore, federally-funded food safety projects, and even industry-centered projects, increasingly involve large, multidisciplinary/multiinstitutional collaborative teams. However, very few individuals thrust into these roles have formal education or training in managing such projects. This symposium brings together a unique and diverse cohort of presenters, ranging from an expert on assessing the effectiveness and impact of research collaborations and centers (with experience on multiple food safety project teams) to experienced managers of such projects (in government, academic, and industry) to a representative of the Scientific Integrity Consortium. The speakers will describe measures for evaluating the effectiveness of such largescale collaborations, identify common features of successful collaborations, share best practices for forming and managing such teams, and outline essential foundational principles for ensuring the quality and integrity of the resulting research. A panel discussion is included to maximize opportunities for attendee interaction with the multiple perspectives provided by the speakers. After this session, attendees will have a better appreciation on how to play together well in the research sandbox.

Conveners: Bradley Marks, Michigan State University; Kendra Nightingale, Texas Tech University; and Isabel Walls, USDA NIFA

Scholarly Assessment of Large Scholarly Collaboration: Measures of Effectiveness and Impact
Denis Gray, PhD, North Carolina State University Managing Government-Academic-Industry Collaborations
Kimberly Cook, PhD, USDA ARS Lessons Learned from Managing NoroCORE, a Large USDA-CAP Project
Lee-Ann Jaykus, PhD, North Carolina State University Managing Food Safety Projects Across Multiple Boundaries - Internally and Externally
Edith Wilkin, PhD, Leprino Foods Report from the Scientific Integrity Consortium: Principles and Best Practices for Scientific Integrity
Linda Harris, PhD, University of California, Davis

This session is supported by the IAFNS Food Microbiology Commitee.

The Mitigation and Regulation of Heat-Formed Substances Produced in Foods During Cooking: What are the Unintended Consequences on Microbial Safety and Public Health? Expand

Tuesday, July 23, 2019 | 10:45 AM - 12:15 PM | M107

A growing field in food safety is the focus on the potential risk of heat-formed substances produced during cooking. Compounds that are known as human health hazards are being increasingly identified as heat-formed substances present in food. Two prominent examples of this are acrylamide and furfuryl alcohol, both of which are present in significant amounts in a wide array of foods. This session will help inform how the risk assessment process of heat-formed substances can incorporate the benefits of cooking and cooked food. It will highlight the genetic changes that allowed humans to consume cooked food. The session will then explore the unintended consequences in mitigating heat formed substances, such as introducing microbial hazards. It will address how to assess and communicate these risks to food processors and consumers. The potential impact and implications on the food industry and, ultimately, the end consumer, of using current approaches to assess the potential public health impact of compounds formed during routine cooking of food will be debated.

Convener: Steven Hermansky, PharmD, PhD, DABT, ConAgra Brands

Genetic Evidence of Human Adaptation to a Cooked Diet and its Role in Human Health and Food Safety - Video not available
Steven Hermansky, PharmD, PhD, DABT, ConAgra Brands Balancing Microbial Food Safety Risks with Mitigating Heat-Formed Substances in Foods - Video not available
Scott Hood, PhD, General Mills The Need for a Holistic Toxicological Assessment of Heat-formed Substances within A Food Matrix -Video
Michael Dourson, PhD, DABT, FATS, FSRA, Toxicology Excellence for Risk Assessment

This session is supported by the IAFNS Food and Chemical Safety Committee.

Let's Hear from Next Generation Food Safety Scientists on Pathogen Behavior in Ready to Eat Foods Expand

Wednesday, July 24, 2019 | 1:30 - 3:30 PM | Ballroom E

A current research collaboration between Health Canada, the University of Guelph and North Carolina State University is investigating the survival and inactivation of Listeria monocytogenes, Salmonella, and foodborne viruses during the storage of low moisture foods. This is a wide-ranging research consortium funded by the IAFNS Food Microbiology Committee and includes a number of developing research scientists who will also present their findings. The IAFNS Food Microbiology Committee is committed to proactively improving the understanding and control of microbial food safety hazards to enable scientifically informed decision making. The Committee achieves its mission by funding research that is conducted at institutions who also train the next generation of food safety scientists.

Ready-to-eat low moisture products such as nuts, dried fruits, cereal products, and chocolate are often ingredients used in the manufacturing of many food products. They carry significant potential for the amplification of outbreaks and recalls over a wide variety of products. The research consortium represented by this next generation of food safety experts is studying several aspects of pathogen behavior in low moisture ready-to-eat foods and goes beyond traditional thermal mitigation strategies.

Conveners: Laurie Post, PhD, Deibel Labs; Edith Wilkin, PhD, Leprino Foods

Survival, Inactivation and Detection of Foodborne Viruses During Long Term Storage in Chocolate, Pistachios and Cornflakes
Neda Nasheri, PhD, Health Canada Survival and Virulence of L. monocytogenes During Storage on Low Moisture Foods and Characterization of the Low Moisture Foods Microbiome
Vivian Ly, MSc candidate, University of Guelph Nontraditional Decontamination Methods for Salmonella Reduction in Dried Fruits and Cereals
Kayla Murray, PhD candidate, University of Guelph Identification of Molecular Mechanisms Mediating Long-Term Survival of Salmonella in Pistachios, Dried Apples, and Cornflakes
Victor Oladimeji Jayeola, PhD candidate, North Carolina State University

This session is supported by the IAFNS Food Microbiology Committee.

Roundtable Event:

Is It Time for Food Safety Performance Standards Since Zero Risk Is Not an Option? Expand

Monday, July 22, 2019 | 10:45 AM - 12:15 PM | Ballroom E

Food safety systems rely on verification activities to determine if the system is working as designed and validated. Microbiological performance standards can be used to verify if a processing system is adequately controlling a specific hazard. Performance standards should be set to protect public health. Sampling protocols and microbiological testing methods must be appropriate for the food being tested. In the US poultry industry, performance standards have been in place to measure the prevalence of Salmonella. Over time, the performance standards have changed to reflect the improved conditions in the industry. Prevalence based performance standards may work for other product categories, especially in dry products of raw agricultural products such as wheat flours and the produce area especially for frozen fruits and vegetables. This roundtable discussion will explore the current and potential future uses of performance standards in foods where it is not reasonable to expect zero presence of pathogens.

Convener: Christina Stam, PhD, Kraft Heinz

Panelists:
Craig Hedberg, PhD, University of Minnesota
Candace Doepker, PhD, ToxStrategies
Angie Siemens, PhD, Cargill
Scott Hood, PhD, General Mills
Donna Garren, PhD, American Frozen Food Institute

This roundtable event is supported by the IAFNS Food Microbiology Committee.

Poster Presentations:

A Novel Simulation Approach to Improving the Effectiveness of Sampling for Bulk Food Products - Video
Eric Cheng, University of Illinois | P1-124 | Monday, July 22, 8:30am - 6:15pm Global Gene Expression Analysis of Salmonella Contaminating Low-Moisture Foods - Video
Victor Oladimeji Jayeola, North Carolina State University | P1-201 | Monday, July 22, 8:30am - 6:15pm Prevalence and Characteristics of Selected Foodborne Bacterial Pathogens in Post-Hurricane Florence Floodwaters - Video
Jeff Niedermeyer, North Carolina State University | P3-161 | Wednesday, July 24, 8:30am - 3:30pm

Learn more about the IAFP Annual Meeting here.

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The IAFNS Mid-Year Meeting combines presentations on topics of current interest with reports on progress within the organization's new and ongoing programs. The 2019 Mid-Year Meeting will be held on Tuesday, 25 June 2019.

This year's program will address the impact of deep and prolonged space travel on human physiology and technologies for developing a safe and nutritious food supply in space. The program also features top speakers to discuss emerging science on food waste and environmental sustainability, risk assessment and bias reduction tools for scientific research.

Registration

Register early to secure your spot at the IAFNS Mid-Year Science Program. This event is open to the public and space is limited.

Registration Rates:

Early Bird (through 26 April) Regular Rate
Students $50 $75
Academic $100 $150
Government $0 $0
Non-Profit $150 $200
Private $200 $250

 

Location

The 2019 IAFNS Mid-Year Science Program will be held at:

Key Bridge Marriott
1401 Lee Highway
Arlington, Virginia 22209 Accommodations

A group rate of $229/night (plus tax) is available at the Key Bridge Marriott for IAFNS Mid-Year Science Program attendees. To secure this rate, attendees must make their accommodations by Friday, May 31st 2019.

Key Bridge Marriott
1401 Lee Highway
Arlington, Virginia 22209

 

View all Scientifc Presentation Videos

Scientific Presentations:

Films from the Future: Technology and Morality in the Sciences
Andrew Maynard, PhD, Arizona State University Methods, Technologies & Requirements for Developing a Safe, Nutritious & Palatable Food System in Space
Grace Douglas, PhD, NASA Nutritional Requirements for Space Explorers
Scott Smith, PhD, NASA Considerations for Food Production and Life Support in Space
Michael Dixon, PhD, University of Guelph Relationship Between Food Waste, Diet Quality & Environmental Sustainability
Zach Conrad, PhD, MPH, College of William & Mary Impact of Environmental Microbes on Listeria and Salmonella
Chuck Czuprynski, PhD, UW Food Research Institute Dietary Effects on Host Metabolism and Health: Role of the Gut Microbiota? (Video not available)
Kelly Swanson, PhD, University of Illinois Urbana-Champaign New Frameworks & Surrogate Approaches to Risk Assessment
Thomas Hartung, MD, PhD, Johns Hopkins Benefits of More Transparent Research Practices and Bias Reduction Tools
David Mellor, PhD, Center for Open Science Update on IAFNS Assembly on Scientific Integrity (Video not available)
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