There is evidence of a significant dose-dependent linear relationship between industrial trans fatty acids (iTFA) intake from partially hydrogenated oils and low-density lipoprotein cholesterol (LDL-C), a validated surrogate marker of coronary heart disease risk. The aim of this study is to conduct a meta-regression of controlled clinical trial data to investigate quantitatively the relationship between dietary intake of iTFAs and increased LDL-C, and to systematically consider the data relating to the mode of action for the effects of iTFAs on plasma LDL-C levels.
Institution: Toxicology Excellence for Risk Assessment
Principal Investigator: Lynne Haber, PhD
Year Awarded: 2015
Mode-of-action evaluation for the effect of trans fatty acids on low-density lipoprotein cholesterol
Meta-regression analysis of the effect of trans fatty acids on low-density lipoprotein cholesterol
View Part 1 of this project: Trans Fatty Acids and Cholesterol Levels: An Evidence Map of the Available Science
Learn more about the IAFNS Partially Hydrogenated Oils Committee.