Review of EU Novel Food submissions and US GRAS Petitions to identify opportunities for use of New Approach Methodologies for safety determinations of food substances

The risk assessment of some food substances have been shifting to adoption of a high-throughput, non-animal method strategy for demonstrating safety. These methods, along with new in vitro, in silico and powerful computer modeling tools, are collectively referred to as New Approach Methodologies or NAMs. This project seeks to review available safety assessments of food substances to identify classes of food substances that have leveraged NAMs data to support a regulatory approval. This will include a review of safety determinations by the U.S. Food & Drug Administration in its publicly available GRAS database, as well as those from the European Food Safety Authority and Health Canada.

Principal Investigator: Craig Llewelyn

Organization: Exponent

Year: 2024

Awarded by IAFNS Food Chemical Safety Committee