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							Official Program
					
			About this session
							Expand
		

While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews", as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., "Effects of caffeine on human health", there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos Expand Welcome
Alison Kretser, MS, RD, IAFNS The Caffeine Landscape - framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 - 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video

Results of Specific Health Endpoints- Scientific Advisory Board Members

  • Harris Lieberman, US Army - Behavior - Video 
  • Charles O'Brien, University of Pennsylvania - Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma - Reproductive & Developmental Toxicity - Video 
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine- Cardiovascular - Video 
  • Connie Weaver, PhD, Purdue University - Bone & Calcium - Video 
  • Milton Tenenbein, MD, University of Manitoba - Acute & Pharmacokinetics - Video 
Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of IAFNS (Oversight Committee) Overall Conclusions - presented by Daniele Wikoff
Full session playlist  CoffeeBambooSmall

See IAFNS's other sessions at Experimental Biology 2017:

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Saturday, 22 April 2017
8:30AM - 12:30PM
Ballroom S100BC
Speakers: Dennis Keefe, FDA; Harris Lieberman, USARIEM; Esther Myers, EF Myers Consulting; Charles O'Brien, University of Pennsylvania; Jennifer Peck, University of Oklahoma; Milton Tenenbein, University of Manitoba; Connie Weaver, Purdue University; Daniele Wikoff, ToxStrategies
Supported by the Caffeine Working Group
Session Info & Videos The Changing Brain: How Brain Plasticity, Exercise and Nutrition Affect Function and Cognition
Saturday, 22 April 2017
3:00PM - 5:00PM,
Ballroom S100BC
  • Neurogensis and brain plasticity in the adult brain - Henriette van Praag, National Institute on Aging;
  • The Relation of Exercise, fitness, & Adiposity to Cognitive and Brain Health - Charles Hillman, University of Illinois - Video
  • Neuroinflammatory Processes in Cognitive Disorders - Sophie Laye, Universite Bordeaux - Video
  • Exercise, Nutrition and Brain Funciton: What are the steps toward dietary and physical activity Recommendations? - Mary Ann Johnson, University of Georgia - Video
  • Panel Discussion - Video
Utility of Predictive Modeling for Nutrition Research, Clinical Interventions and Public Health
Sunday, 23 April 2017
8:30AM- 10:30AM
S105BCD
Speakers:
  • Intro to Predictive Modeling: From Linear Regression Models to Mechanistic Mathematical Modeling - David Allison, University of Alabama at Birmingham - Video;
  • Use of Predictive Modeling in the Design of Clinical Studies Kevin Hall, NIDDK - Video;
  • Application of Predictive Modeling in Weight Loss Counseling -  Corby Martin, Pennington Biomedical Research Center - Video;
  • Application of Predictive Modeling in Personalized Nutrition - Ben van Ommen, TNO - Video;
  • Utility of PRedictive Modeling for Public Health Obesity Policies - Emily Dhurandhar, Texas Tech University - Video;
  • Summary and Wrap-Up - Diana Thomas, West Point - Video
    Supported by the Protein Committee
  • Full session playlist
Learning Lab: How to Access and Use a Fiber and Health Outcomes Database for Researchers and Policymakers
Tuesday, 25 April 2017
11:00AM - 12:30PM
S105AB
Speakers: Kara Livingston, Tufts University; Caleigh Sawicki, Tufts University
Supported by the Carbohydrate Committee Posters
Sources of dietary folate/folic acid in women of different races in the United States between 2009 and 2012: What is the role of fortified and enriched products?
PDF
Abstract Number: 6707
Poster Board Number C88
Presenter: Ray DeVirgiliis, George Washington University
Monday, 24 April
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Co-hosted by U.S. Food and Drug Administration, Center for Food Safety & Applied Nutrition (CFSAN) and the IAFNS Technical Committee on Food & Chemical Safety

This workshop will bring together scientists from government, academia and industry to discuss the advances in testing strategies to reduce animal testing and the need for the development of a standardized approach for use of these alternative methodologies in food safety assessment.

Workshop Proceedings:

State of the Science on Alternatives to Animal Testing and Integration of Testing Strategies for Food Safety Assessments

Read the Proceedings Registration Expand

There is no fee to attend the workshop but, registration is required by Tuesday, February 21. Please register for the workshop using this link: Workshop Registration

Webcast Registration
Register for webcast here: webcast registration
Webcast participants can submit questions online during the event. These will be answered as time allows. Agenda Expand

8:30-8:40 am: Welcome Suzanne Fitzpatrick, FDA Mansi Krishan, IAFNS

8:40-8:55am
Introductory Remarks
Dennis Keefe, FDA
Heidi Bialk, IAFNS Member Scientist 8:55-9:35am
Integrated Testing Strategies in Food Safety
Alan Boobis, Imperial College London [30 mins + 10 mins Q & A] 9:35-10:15am
State of the Science on High Through-Put Screening (HTS): Food Safety Perspective
Nadine Bewry, FDA 10:30-11:10am
Case Studies to Describe the Limitations of Using HTS data in Food Safety Assessment
Rebecca Clewell, ScitoVation 11:10 -11:50am
Identify and Translate Learnings from On-Going Assay Validation Efforts into Standard HTS Testing Practices
Richard Judson, EPA 12:50- 1:30pm
Read Across Approaches: Chemical Structure and Bioactivity Profiling Applicable to Food Safety
Grace Patlewicz, EPA 1:30-2:10pm
FDA Perspective on Read Across Approaches
Tim Adams, FDA 2:10-2:50 pm
Organ on a Chip Technology
Daniel Levner, Emulate 3:05- 4:30pm
Panel Discussion Moderator: Suzanne Fitzpatrick, FDA Panelists:
All speakers, Thomas Hartung, Johns Hopkins University and Katya Tsaioun, Johns Hopkins University 4:30-4:40pm
Concluding Remarks
Suzanne Fitzpatrick
FDA Mansi Krishan, IAFNS Videos Expand

A video of the workshop can be found on the FDA YouTube channel

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While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews", as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., "Effects of caffeine on human health", there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos Expand Welcome
Alison Kretser, MS, RD, IAFNS The Caffeine Landscape - framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 - 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video

Results of Specific Health Endpoints- Scientific Advisory Board Members

  • Harris Lieberman, US Army - Behavior - Video 
  • Charles O'Brien, University of Pennsylvania - Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma - Reproductive & Developmental Toxicity - Video 
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine- Cardiovascular - Video 
  • Connie Weaver, PhD, Purdue University - Bone & Calcium - Video 
  • Milton Tenenbein, MD, University of Manitoba - Acute & Pharmacokinetics - Video 
Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of IAFNS (Oversight Committee) Overall Conclusions - presented by Daniele Wikoff
Full session playlist  CoffeeBambooSmall

See IAFNS's other sessions at Experimental Biology 2017:

Full Schedule Learn more [post_title] => Conducting a Systematic Review for a Global Audience: Challenges in Merging Nutrition and Toxicological Evidence for a Safety Assessment of Caffeine [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => experimental-biology-2017-2 [to_ping] => [pinged] => [post_modified] => 2021-02-09 16:44:05 [post_modified_gmt] => 2021-02-09 16:44:05 [post_content_filtered] => [post_parent] => 0 [guid] => https://iafnsconnect.wpengine.com/?post_type=event&p=2388 [menu_order] => 0 [post_type] => event [post_mime_type] => [comment_count] => 0 [filter] => raw ) [comment_count] => 0 [current_comment] => -1 [found_posts] => 19 [max_num_pages] => 4 [max_num_comment_pages] => 0 [is_single] => [is_preview] => [is_page] => [is_archive] => [is_date] => [is_year] => [is_month] => [is_day] => [is_time] => [is_author] => [is_category] => [is_tag] => [is_tax] => [is_search] => [is_feed] => [is_comment_feed] => [is_trackback] => [is_home] => 1 [is_privacy_policy] => [is_404] => [is_embed] => [is_paged] => 1 [is_admin] => [is_attachment] => [is_singular] => [is_robots] => [is_favicon] => [is_posts_page] => [is_post_type_archive] => [query_vars_hash:WP_Query:private] => b692340bd2edd989c384be3e1209b726 [query_vars_changed:WP_Query:private] => [thumbnails_cached] => [allow_query_attachment_by_filename:protected] => [stopwords:WP_Query:private] => [compat_fields:WP_Query:private] => Array ( [0] => query_vars_hash [1] => query_vars_changed ) [compat_methods:WP_Query:private] => Array ( [0] => init_query_flags [1] => parse_tax_query ) )


2021

NUTRITION 2021

Virtual, Event

Food Biome to Human Biome: Beyond Nutrients

Gut microbiota is intertwined with host metabolism, immune function, and psychological state. Learn how foods we consume are one of the main drivers that shift microbiota profile and functionalities.

Read more about NUTRITION 2021

Webinar Series: Improving the Healthspan of Older Adults Through Nutrition

Virtual, Webinar

Current research on aging reveals it is possible to extend healthspan while delaying, and in some cases, preventing many chronic diseases associated with aging through nutrition and interventions targeted at cellular degeneration. This webinar series is a collaboration with the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (HNRCA).

Read more about Webinar Series: Improving the Healthspan of Older Adults Through Nutrition

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				HNRCA webinar LI (4)
				tufts-logo-small
	

Webinars will be held from 3pm to 430pm ET across four Thursdays. Time is reserved for Questions & Answers in each session. Details for each session are noted below.  The series is free and open to the community.

Current research on aging reveals it is possible to extend healthspan while delaying, and in some cases, preventing many chronic diseases associated with aging through nutrition and interventions targeted at cellular degeneration.

This webinar series is a collaboration with the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (HNRCA). HNRCA is a leader in food, nutrition, and healthy aging research and has trained hundreds of Tufts University students who have become successful in academia, industry, and government. Join current scientists from the HNRCA as they share their latest research on how food and nutrition are critical determinants to a healthy and independent lifestyle for older adults. Talks will present research that focuses on the biology of aging at the cellular level all the way to how to directly impact healthspan through diet and physical activity.

 

March 4

Improving the Healthspan of Older Adults Through Nutrition: The biology of aging

We know age is a risk factor for many chronic diseases and research also shows that disease can accelerate the aging process and shorten a person's healthspan. During this webinar we will examine the role of inflammation and other cellular processes in older adults and possible interventions, including diet, that may slow or stop degenerative diseases and extend quality of life. Understanding the biology of aging is a vital part of unlocking many of the unknowns associated with aging.

Speakers:

Sarah Booth, Ph.D.
Center Director; Senior Scientist and lead, Vitamin K team Simin Meydani, D.V.M., Ph.D.
Senior Scientist and lead, Nutritional Immunology Team Christopher Wiley, Ph.D.
Scientist II, Nutrition, Metabolism and Cellular Aging Team

March 25

Improving the Healthspan of Older Adults Through Nutrition: Balancing a healthy weight while meeting nutritional needs for bone and muscle health

This webinar addresses the fact that older adults need to reduce their daily calorie intake. How do you do this and maintain a healthy body weight and be sure we address bone and muscle health? To maintain bone health, it's vital to obtain calcium combined with vitamin D, which helps the body absorb calcium. Continuing their ground-breaking research on musculoskeletal health, HNRCA scientists will share their latest findings on the detrimental effect acid-producing diets have on bone and muscle and considering what we have learned from the recent vitamin D mega-trials.

Speakers:

Lisa Ceglia, M.D.
Scientist II and Director, Metabolic Bone Diseases Clinic, Tufts Medical Center Bess Dawson Hughes, M.D.
Senior Scientist, Bone Metabolism Team Susan Roberts, Ph.D.
Senior Scientist and Lead, Energy Metabolism Team

April 15

Improving the Healthspan of Older Adults Through Nutrition: Delaying age-related eye diseases

The risk of age-related eye diseases such as macular degeneration, cataracts, and glaucoma can be reduced by eating a dietary pattern with plenty of fruits and vegetables and complex carbohydrates such as whole grains. HNRCA investigators have shown that diets high in simple carbs such as white bread and carbonated beverages create spikes in blood sugar leading to widespread inflammation, a condition linked to age-related macular degeneration. In this webinar they will share novel findings on the link between the gut microbiota and eye health and possible interventions to delay eye disease in older adults.

Speakers:

Sheldon Rowan, Ph.D.
Scientist II, Nutrition and Vision Research Team Kelsey Smith, M.S.
Tufts Doctoral Student, Nutrition and Vision Research Team

May 6

Improving the Healthspan of Older Adults Through Nutrition: Delaying cognitive decline

Regular exercise and healthy dietary patterns that focus on whole grains, berries, leafy green vegetables and healthy fats are proving to have a positive effect in improving or delaying cognitive decline in older adults. HNRCA researchers will share observational findings as well as the results of community-based programs promoting the benefits of physical activity on cognition. In this webinar HNRCA scientists will also discuss promising results of animal studies involving the generation of new brain cells that may lead to interventions that improve memory function in older adults.

Speakers:

Paul Jacques, D.Sc.
Senior Scientist and lead, Nutritional Epidemiology Team Kieran Reid, Ph.D., M.P.H.
Scientist I, Nutrition, Exercise Physiology and Sarcopenia Team Tong Zheng, Ph.D.
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