Standardizing Method and Development of Normal Values to Measure Human Small Intestinal and Colonic Permeability

Maintaining—or restoring to normal—gut barrier function is not currently recognized as a physiologic benefit of fiber consumption, in part due to lack of agreement by experts in the field on how to define and measure normal gut barrier function in human nutrition research. An IAFNS sponsored expert panel published an article in 2019 summarizing the foundational science related to normal gut structure and function as well as how to measure it. The panel’s recommended next step is to standardize a method for measuring gut permeability in human subjects and apply the method to initiate the process of quantifying the range of distribution in the general healthy public. The objective is to assess whether variation in the range of fiber representing typical to recommended intakes in the American diet is a critical factor in establishing this standardized method.

Institution: Mayo Clinic
Principal Investigator: Michael Camilleri
Date: 2019

Read more: Development and Validation of Test for 'Leaky Gut' Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults

View this project on the Center for Open Science's Open Science Framework.

This project is supported by the IAFNS Carbohydrates Committee.