The Committee on Food and Chemical Safety promotes a science-based determination of the chemical safety of foods to support the advancement of public health.

How this committee operates:

The Food and Chemical Safety Committee focuses on many different issues related to the safety of the food supply.  To deliver output and impact, the committee works in subgroups focused on specific areas of food and chemical safety.  Explore the work of the Committees below. 

Areas of Work

Food Allergens
Food Allergens

Food allergies affect a significant number of children and adults in the US and globally. Potential exposure to food allergens is currently communicated using ambiguous, unhelpful statements such as “may contain” or “packaged in a facility that also processes”. The committee supported the first study of its kind to model peanut allergen dose-responses based on US clinical tests and estimate thresholds of peanut protein that trigger an adverse reaction. The use of allergen response thresholds has the potential to significantly improve food labeling with measurable benefits to allergic individuals (read the project description here and the publication here).

The Committee was a co-sponsor of the National Academies of Sciences, Engineering, and Medicine (NASEM) report Finding a Path to Safety in Food Allergy.

Next Generation Risk Assessment
Mycotoxins
Heavy Metals

COMMITTEE MEMBERS
Abbott Nutrition
ADM
Cargill, Incorporated
Campbell Soup
Conagra Brands
General Mills, Inc.
The Hershey Company
International Flavors & Fragrances, Inc.
Keurig Dr Pepper​
Kraft Heinz Company
Mondelēz International

ACADEMIC ADVISOR
Norbert Kaminski, PhD, Michigan State University

GOVERNMENT LIAISONS
Suzanne Fitzpatrick, PhD, DABT
U.S. Food and Drug Administration
Center for Food Safety and Applied Nutrition

Randolph Duverna, PhD
U.S. Department of Agriculture
Food Safety & Inspection Service Office of Public Health Service

Katie Weyrauch
U.S Department of Agriculture
Food Safety and Inspection Service

Shoushan Steve Zeng, PhD
U.S Department of Agriculture
National Institute of Food and Agriculture

Louis D'Amico, PhD
U.S. Environmental Protection Agency Office of Research and Development

Join Us!

Student Opportunities

Under the guidance of IAFNS staff and members of the Food and Chemical Safety Committee, the Summer Toxicology Fellowship program allows motivated graduate students to pursue research projects. View past Summer Fellowship projects here.

Projects Supported by the Committee:

Review of EU Novel Food submissions and US GRAS Petitions to identify opportunities for use of New Approach Methodologies for safety determinations of food substances

Heavy Metals in US Foods: Exposure Assessment by Age Group and Mitigation Strategies

A Framework for Heavy Metal Prioritization and Mitigation for Reducing Metal Intake: Rice and Spinach Case Studies

Advancing Exposure Assessment for Food Contaminants Through Implementation of Probabilistic Modeling

Development of a Research Framework for Evidence-Based Assessment of Potential Carcinogens in Human Diets

Updating the Metal Dietary Exposure Screening Tool

Assessing Human Health Impacts of Global Adoption of Codex Deoxynivalenol (DON) Guidelines

Evaluation of the Dose-Response for Peanut Allergen

Evaluating the Applicability of Read-Across Tools and High-Throughput Screening Data for Food Relevant Chemicals

Comparison and Analysis of Toxcast Data with In Vivo Data for Food-Relevant Compounds Using The Risk21 Approach

Evaluation of Arsenic-Induced Intracytoplasmic Inclusions

Evaluating the Association between Dietary Exposure to Inorganic Arsenic on Health Outcomes for the US Population

An Approach to Standardize the Concepts of Low Dose and Nonmonotonic Dose Response in Toxicological Research and Regulatory Science

Toxicology and Risk Assessment of Chemical Mixtures

Evaluation of Food-Relevant Chemicals in ToxCast Phase II

Past Publications

Filter

Oldest to Newest

Evaluating the Applicability of a Risk-based Approach (Decision Tree) to Mycotoxins Mitigation

Food Protection Trends, 2019

The primary aim of this work was to evaluate a hypothesis on whether a foundational framework (decision tree) previously developed by the North American Branch of the International Life Sciences Institute (IAFNS) Food and Chemical Safety Committee for a risk-based approach to mitigation of process-formed compounds could be applied to other not-readily-avoidable substances, such as mycotoxins.

Read more about Evaluating the Applicability of a Risk-based Approach (Decision Tree) to Mycotoxins Mitigation

Incorporating New Approach Methodologies in Toxicity Testing and Exposure Assessment for Tiered Risk Assessment Using the RISK21 Approach: Case Studies on Food Contact Chemicals

Food and Chemical Toxicology, 2019

This study highlights the potential utility of the RISK21 approach for interpretation of the ToxCast HTS data, as well as the challenges involved in integrating in vitro HTS data into safety assessments. This work was supported by the IAFNS Food and Chemical Safety Committee 2016 Summer Fellowship.

Read more about Incorporating New Approach Methodologies in Toxicity Testing and Exposure Assessment for Tiered Risk Assessment Using the RISK21 Approach: Case Studies on Food Contact Chemicals

State of the Science on Alternatives to Animal Testing and Integration of Testing Strategies for Food Safety Assessments: Workshop Proceedings

Regulatory Toxicology and Pharmacology, 2019

These proceedings highlight advances in testing strategies to reduce animal testing and the need for the development of a standardized approach for use of these alternative methodologies in food safety assessment.

Read more about State of the Science on Alternatives to Animal Testing and Integration of Testing Strategies for Food Safety Assessments: Workshop Proceedings

Global Wheat Trade and Codex Alimentarius Guidelines for Deoxynivalenol: A Mycotoxin Common in Wheat

Global Food Security, 2021

2015 Codex guidelines for a mycotoxin do not appear to be affecting the global wheat trade. Without a core-periphery structure and engaged nations in the center of world wheat trade adopting these guidelines, it may take longer for these guidelines to be widely adopted, and for populations worldwide to benefit from lower exposure to Deoxynivalenol in their diets.

Read more about Global Wheat Trade and Codex Alimentarius Guidelines for Deoxynivalenol: A Mycotoxin Common in Wheat

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Past Events

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                (
                )

            [search_columns] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => post_tag
                            [terms] => Array
                                (
                                    [0] => food and chemical safety
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_term_relationships
                )

            [queried_terms] => Array
                (
                    [post_tag] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => food and chemical safety
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [1] => Array
                        (
                            [0] => Array
                                (
                                    [key] => _ilsi_date
                                    [value] => 2019-04-28
                                    [compare] => >=
                                    [type] => DATE
                                )

                            [1] => Array
                                (
                                    [key] => _ilsi_date
                                    [value] => Array
                                        (
                                            [0] => 2015-01-01
                                            [1] => 2015-12-31
                                        )

                                    [compare] => BETWEEN
                                )

                            [2] => Array
                                (
                                    [key] => _ilsi_date
                                    [value] => 2015-12-31
                                    [compare] => <
                                )

                            [relation] => AND
                        )

                    [relation] => AND
                )

            [relation] => AND
            [meta_table] => wp_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_postmeta
                    [1] => mt1
                    [2] => mt2
                    [3] => mt3
                )

            [clauses:protected] => Array
                (
                    [wp_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_postmeta
                            [cast] => CHAR
                        )

                    [mt1] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2019-04-28
                            [compare] => >=
                            [type] => DATE
                            [compare_key] => =
                            [alias] => mt1
                            [cast] => DATE
                        )

                    [mt2] => Array
                        (
                            [key] => _ilsi_date
                            [value] => Array
                                (
                                    [0] => 2015-01-01
                                    [1] => 2015-12-31
                                )

                            [compare] => BETWEEN
                            [compare_key] => =
                            [alias] => mt2
                            [cast] => CHAR
                        )

                    [mt3] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2015-12-31
                            [compare] => <
                            [compare_key] => =
                            [alias] => mt3
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts  LEFT JOIN wp_term_relationships ON (wp_posts.ID = wp_term_relationships.object_id) INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )  INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )  INNER JOIN wp_postmeta AS mt2 ON ( wp_posts.ID = mt2.post_id )  INNER JOIN wp_postmeta AS mt3 ON ( wp_posts.ID = mt3.post_id )
					WHERE 1=1  AND ( 
  wp_term_relationships.term_taxonomy_id IN (74)
) AND ( 
  wp_postmeta.meta_key = '_ilsi_date' 
  AND 
  ( 
    ( mt1.meta_key = '_ilsi_date' AND CAST(mt1.meta_value AS DATE) >= '2019-04-28' ) 
    AND 
    ( mt2.meta_key = '_ilsi_date' AND mt2.meta_value BETWEEN '2015-01-01' AND '2015-12-31' ) 
    AND 
    ( mt3.meta_key = '_ilsi_date' AND mt3.meta_value < '2015-12-31' )
  )
) AND ((wp_posts.post_type = 'event' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					GROUP BY wp_posts.ID
					ORDER BY wp_postmeta.meta_value DESC
					LIMIT 0, 5
				
    [posts] => Array
        (
        )

    [post_count] => 0
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 0
    [max_num_pages] => 0
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 1
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => b18772c47a4d022fe9a067ea85959ce7
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)