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							Official Program
					
			About this session
							Expand
		

While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews", as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., "Effects of caffeine on human health", there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos Expand Welcome
Alison Kretser, MS, RD, IAFNS The Caffeine Landscape - framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 - 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video

Results of Specific Health Endpoints- Scientific Advisory Board Members

  • Harris Lieberman, US Army - Behavior - Video 
  • Charles O'Brien, University of Pennsylvania - Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma - Reproductive & Developmental Toxicity - Video 
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine- Cardiovascular - Video 
  • Connie Weaver, PhD, Purdue University - Bone & Calcium - Video 
  • Milton Tenenbein, MD, University of Manitoba - Acute & Pharmacokinetics - Video 
Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of IAFNS (Oversight Committee) Overall Conclusions - presented by Daniele Wikoff
Full session playlist  CoffeeBambooSmall

See IAFNS's other sessions at Experimental Biology 2017:

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Saturday, 22 April 2017
8:30AM - 12:30PM
Ballroom S100BC
Speakers: Dennis Keefe, FDA; Harris Lieberman, USARIEM; Esther Myers, EF Myers Consulting; Charles O'Brien, University of Pennsylvania; Jennifer Peck, University of Oklahoma; Milton Tenenbein, University of Manitoba; Connie Weaver, Purdue University; Daniele Wikoff, ToxStrategies
Supported by the Caffeine Working Group
Session Info & Videos The Changing Brain: How Brain Plasticity, Exercise and Nutrition Affect Function and Cognition
Saturday, 22 April 2017
3:00PM - 5:00PM,
Ballroom S100BC
  • Neurogensis and brain plasticity in the adult brain - Henriette van Praag, National Institute on Aging;
  • The Relation of Exercise, fitness, & Adiposity to Cognitive and Brain Health - Charles Hillman, University of Illinois - Video
  • Neuroinflammatory Processes in Cognitive Disorders - Sophie Laye, Universite Bordeaux - Video
  • Exercise, Nutrition and Brain Funciton: What are the steps toward dietary and physical activity Recommendations? - Mary Ann Johnson, University of Georgia - Video
  • Panel Discussion - Video
Utility of Predictive Modeling for Nutrition Research, Clinical Interventions and Public Health
Sunday, 23 April 2017
8:30AM- 10:30AM
S105BCD
Speakers:
  • Intro to Predictive Modeling: From Linear Regression Models to Mechanistic Mathematical Modeling - David Allison, University of Alabama at Birmingham - Video;
  • Use of Predictive Modeling in the Design of Clinical Studies Kevin Hall, NIDDK - Video;
  • Application of Predictive Modeling in Weight Loss Counseling -  Corby Martin, Pennington Biomedical Research Center - Video;
  • Application of Predictive Modeling in Personalized Nutrition - Ben van Ommen, TNO - Video;
  • Utility of PRedictive Modeling for Public Health Obesity Policies - Emily Dhurandhar, Texas Tech University - Video;
  • Summary and Wrap-Up - Diana Thomas, West Point - Video
    Supported by the Protein Committee
  • Full session playlist
Learning Lab: How to Access and Use a Fiber and Health Outcomes Database for Researchers and Policymakers
Tuesday, 25 April 2017
11:00AM - 12:30PM
S105AB
Speakers: Kara Livingston, Tufts University; Caleigh Sawicki, Tufts University
Supported by the Carbohydrate Committee Posters
Sources of dietary folate/folic acid in women of different races in the United States between 2009 and 2012: What is the role of fortified and enriched products?
PDF
Abstract Number: 6707
Poster Board Number C88
Presenter: Ray DeVirgiliis, George Washington University
Monday, 24 April
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Co-hosted by U.S. Food and Drug Administration, Center for Food Safety & Applied Nutrition (CFSAN) and the IAFNS Technical Committee on Food & Chemical Safety

This workshop will bring together scientists from government, academia and industry to discuss the advances in testing strategies to reduce animal testing and the need for the development of a standardized approach for use of these alternative methodologies in food safety assessment.

Workshop Proceedings:

State of the Science on Alternatives to Animal Testing and Integration of Testing Strategies for Food Safety Assessments

Read the Proceedings Registration Expand

There is no fee to attend the workshop but, registration is required by Tuesday, February 21. Please register for the workshop using this link: Workshop Registration

Webcast Registration
Register for webcast here: webcast registration
Webcast participants can submit questions online during the event. These will be answered as time allows. Agenda Expand

8:30-8:40 am: Welcome Suzanne Fitzpatrick, FDA Mansi Krishan, IAFNS

8:40-8:55am
Introductory Remarks
Dennis Keefe, FDA
Heidi Bialk, IAFNS Member Scientist 8:55-9:35am
Integrated Testing Strategies in Food Safety
Alan Boobis, Imperial College London [30 mins + 10 mins Q & A] 9:35-10:15am
State of the Science on High Through-Put Screening (HTS): Food Safety Perspective
Nadine Bewry, FDA 10:30-11:10am
Case Studies to Describe the Limitations of Using HTS data in Food Safety Assessment
Rebecca Clewell, ScitoVation 11:10 -11:50am
Identify and Translate Learnings from On-Going Assay Validation Efforts into Standard HTS Testing Practices
Richard Judson, EPA 12:50- 1:30pm
Read Across Approaches: Chemical Structure and Bioactivity Profiling Applicable to Food Safety
Grace Patlewicz, EPA 1:30-2:10pm
FDA Perspective on Read Across Approaches
Tim Adams, FDA 2:10-2:50 pm
Organ on a Chip Technology
Daniel Levner, Emulate 3:05- 4:30pm
Panel Discussion Moderator: Suzanne Fitzpatrick, FDA Panelists:
All speakers, Thomas Hartung, Johns Hopkins University and Katya Tsaioun, Johns Hopkins University 4:30-4:40pm
Concluding Remarks
Suzanne Fitzpatrick
FDA Mansi Krishan, IAFNS Videos Expand

A video of the workshop can be found on the FDA YouTube channel

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While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews", as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., "Effects of caffeine on human health", there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos Expand Welcome
Alison Kretser, MS, RD, IAFNS The Caffeine Landscape - framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 - 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video

Results of Specific Health Endpoints- Scientific Advisory Board Members

  • Harris Lieberman, US Army - Behavior - Video 
  • Charles O'Brien, University of Pennsylvania - Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma - Reproductive & Developmental Toxicity - Video 
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine- Cardiovascular - Video 
  • Connie Weaver, PhD, Purdue University - Bone & Calcium - Video 
  • Milton Tenenbein, MD, University of Manitoba - Acute & Pharmacokinetics - Video 
Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of IAFNS (Oversight Committee) Overall Conclusions - presented by Daniele Wikoff
Full session playlist  CoffeeBambooSmall

See IAFNS's other sessions at Experimental Biology 2017:

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2022

“Crash Course” on Design and Interpretation of Gut Microbiome Research

Virtual, Event

Effective application of gut microbiome research requires clinicians to critically appraise methodological elements of research when interpreting results. In this webinar, an overview of best practices for designing and conducting diet-microbiome research in humans will be provided. Topics will include not only intervention study designs but also recruitment tips, sampling methods, important metadata to collect, and more. 

Read more about “Crash Course” on Design and Interpretation of Gut Microbiome Research

What is “Sweetness”? The Biological Drive For Sweet Taste and Role in Quality of Life for Individuals with T1DM

Virtual, Event

In this session, the biology of sweet taste and its role in the total diet will be reviewed. In addition, new data from a study assessing the relationship between LNCS use and QoL in adults with Type I Diabetes will be presented.

Read more about What is “Sweetness”? The Biological Drive For Sweet Taste and Role in Quality of Life for Individuals with T1DM

GS1 Connect 2022

San Diego, CA

IAFNS is representing the Partnership on the USDA Global Branded Food Products Database at GS1 Connect 2022. This event brings trading partners together to learn about standards-based business processes and best practices for optimum efficiencies in managing the supply and demand sides of their value chain

Read more about GS1 Connect 2022

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Join IAFNS at the American Society for Nutrition Annual meeting - NUTRITION 2022 - to learn about some of our funded projects.

Diet-Related and Gut-Derived Metabolites and Health Outcomes: A Scoping Review: Abstract Presentation Number: PO24-19-22 Expand Presenting Author: Yuanxi Jia, Johns Hopkins University
Topical Area: Nutritional Microbiology/Microbiome
Supported by: IAFNS Gut Microbiome Committee
For more information, see here.

ABSTRACT

Objectives: To conduct a scoping review to map available evidence about the health impact of gut microbiota-derived metabolites in humans.

Methods: We searched PubMed and Embase for studies that assessed the health impact of gut microbiota-derived metabolites in humans. We included case-control studies, cross-sectional studies, cohort studies, and clinical trials. Any health condition was considered. Based on an initial prioritization phase informed by preliminary searching and expert input, we narrowed our scope to ten metabolites: deoxycholate or deoxycholic acid (DCA), lithocholate or lithocholic acid (LCA), glycolithocholate or glycolithocholic acid, glycodeoxycholate or glycodeoxycholic acid, tryptamine, putrescine, d-alanine, urolithins, N-acetylmannosamine, and phenylacetylglutamine. We used evidence mapping to identify evidence gaps and associations that may permit future systematic reviews. The screening was conducted in PICO Portal aided by artificial intelligence.

Results: Overall, for these 10 metabolites, we identified 352 studies with 168,072 participants. Most (326, 92.6%) were case-control studies, followed by cohort studies (14, 4.0%), clinical trials (8, 2.3%), and cross-sectional studies (6, 1.7%). Most studies assessed the following associations: DCA on hepatobiliary disorders (64 studies, 7,976 participants), colorectal cancer (19 studies, 7,461 participants), and other digestive disorders (27 studies, 2,463 participants); LCA on hepatobiliary disorders (34 studies, 4,297 participants), colorectal cancers (14 studies, 4,955 participants), and other digestive disorders (26 studies, 2,117 participants); putrescine on colorectal cancers (16 studies, 94,399 participants) and cancers excluding colorectal and hepatobiliary cancers (42 studies, 4,250 participants).

Conclusions: The association of gut microbiota-derived metabolites and human health is being examined in an increasing number of studies, most of which are case-control studies. As these metabolites hold considerable potential for elucidating microbiome-disease associations, there is a need to conduct more prospective studies including clinical trials. Moreover, systemic reviews are needed to characterize the metabolite-disease associations.

Funding Sources: Institute for the Advancement of Food and Nutrition Sciences (IAFNS)

Relationship Between Exposure to Dietary Sweetness and Body Weight-Related Outcomes in Adults: An Evidence Map: Abstract Presentation Number: PO08-20-22 Expand Presenting Author: Kelly A. Higgins, USDA, ARS
Topical Area: Dietary Patterns
Supported by: IAFNS Carbohydrates and Low- and No-Calorie Sweeteners Committees
For more information, see here. 

ABSTRACT

Objectives: An evidence map was conducted to characterize published research investigating dietary sweetness and body weight. The primary aim was to identify studies that investigate total dietary sweetness and body weight-related outcomes among healthy adults; the secondary aim was to map the evidence that investigates sugar, sweetener, or sweet food/beverage intake and body weight.

Methods: Using pre-registered search terms (https://osf.io/my7pb), 33,609 publications (duplicates removed) from PubMed, Cochrane Library, and Scopus were screened for inclusion. Eligible studies were cross-sectional studies, longitudinal cohort studies, case control studies, clinical trials, and systematic reviews conducted among adults (≥18 years) which investigated the associations between total dietary sweetness, sugar, sweetener (energetic or nonenergetic), or sweet food/beverage intake on body weight, body mass index, adiposity, and energy intake.

Results: A total of 824 eligible publications were identified. Two clinical trials and 5 cross-sectional studies investigated the associations between total dietary sweetness and a body weight-related outcome. An additional 630 publications were identified that investigated sugar, sweetener, or sweet food/beverage intake and body weight-related outcomes, including 225 clinical trials, 87 longitudinal cohort studies, and 298 cross-sectional studies. Ninety publications reported on dietary patterns that included sweet foods/beverages alongside other dietary components. Most studies (91%) did not measure the sweetness of the diet or individual foods consumed. Additionally, 97 systematic reviews that addressed relevant but different research questions related to sweetness exposure and body weight-related outcomes were identified.

Conclusions: While there is a breadth of evidence available from studies that investigate sugar, sweetener, and sweet food/beverage intake and body weight, there is limited evidence on the association between total dietary sweetness exposure and body weight.

Funding Sources: USDA Agricultural Research Service, Institute for the Advancement of Food and Nutrition Sciences

Quality of Popular Diets in the United States: Abstract Presentation Number: PO08-09-22 Expand Presenting Author: Zach Conrad, William & Mary
Topical Area: Dietary Patterns
Supported by: IAFNS Carbohydrates Committee
For more information, see here.

ABSTRACT

Objectives: 1) Evaluate the quality of popular diets in the US, and 2) model the effect of targeted food substitutions on diet quality.

Methods: Dietary data from 34,411 adults ≥20 y were acquired from the National Health and Nutrition Examination Survey, 2005-2018. Usual dietary intake was assessed using the National Cancer Institute's usual intake methodology, and the Healthy Eating Index-2015 was used to evaluate the diet quality of eleven popular diets. A diet model was used to evaluate the effect of targeted food substitutions on diet quality.

Results: Participants that followed a pescatarian diet pattern had the highest diet quality (65.2, 95% CI: 64.0-66.4), followed by vegetarian (63.0, 62.0-63.0), very low grain (62.7, 62.2-63.3), flexible paleo (62.3, 61.1-63.4), low grain (61.2, 60.6-61.9), low-moderate grain (59.7, 59.3-60.2), omnivorous (57.8, 57.5-58.1), restricted carbohydrate (56.9, 56.6-57.3), time restricted (55.2, 54.8-55.5), moderate protein (55.0, 54.7-55.3), and high protein (51.8, 51.0-62.7). Modeled replacement of up to three daily servings of foods highest in added sugar, sodium, and saturated fat with alternative foods led to a statistically significant increase in diet quality and a decrease in energy intake for most diets (P < 0.001 for most diets).

Conclusions: Low diet quality was observed for all popular diets evaluated in this study. Modeled dietary shifts that align with recommendations to choose foods lower in added sugar, sodium, and saturated fat led to only modest improvements in diet quality but a larger reduction in energy intake. Greater efforts are needed to shift consumer perceptions away from reductionist dietary approaches that place undue emphasis on specific foods, individual macronutrients, and timing of eating, and toward healthy dietary patterns that emphasize consumption of a variety of high-quality food groups.

Funding Sources: This work was supported by the Institute for the Advancement of Food and Nutrition Sciences (IAFNS) Carbohydrate Committee. IAFNS is a nonprofit science organization that pools funding from industry collaborators and advances science through the in-kind and financial contributions from public and private sector participants. IAFNS had no role in the design, analysis, interpretation, or presentation of the data and results.

Association Between Restricted Carbohydrate Diets and Cardiometabolic Disease: Abstract Presentation Number: PO22-26-22 Expand Presenting Author: Corina Kowalski, William & Mary
Topical Area: Nutritional Epidemiology
Supported by: IAFNS Carbohydrate and Lipids Committees 
For more information, see here.

ABSTRACT

Objectives: This study evaluated the association between restricted carbohydrate diets and prevalent cardiometabolic disease (CMD), stratified by fat intake.

Methods: Dietary and CMD data were obtained from 19,078 participants ≥20 y in the National Health and Nutrition Examination Survey (NHANES) 1999-2018. The National Cancer Institute (NCI) methodology was used to assess usual intake of foods and nutrients.

Results: Compared to individuals that met all macronutrient recommendations, those consuming restricted carbohydrate diets ( < 45%en) were 1.123 (95% CI 1.113-1.133) times as likely to have CMD, and those consuming the recommended amount of carbohydrates only were 1.060 (1.058-1.062) times as likely to have CMD. Higher intakes of saturated and polyunsaturated fat were associated with greater prevalence of CMD in restricted and recommended carbohydrate intake groups. Higher intakes of monounsaturated fat were associated with lower prevalence of CMD among participants that met carbohydrate recommendations only.

Conclusions: Participants that consumed restricted carbohydrate diets were more likely to have CMD compared to participants that met all macronutrient recommendations, and this association was modified by fat intake. Greater efforts are needed to understand longitudinal associations between carbohydrate intake and CMD.

Funding Sources: This work was supported by the Institute for the Advancement of Food and Nutrition Sciences (IAFNS) Carbohydrate and Lipid Committees. IAFNS is a nonprofit science organization that pools funding from industry collaborators and advances science through the in-kind and financial contributions from public and private sector participants. IAFNS had no role in the design, analysis, interpretation, or presentation of the data and results.

Restricted Carbohydrate Diets High in Fat Are Associated With Increased Likelihood of Prevalent Metabolic Syndrome: Abstract Presentation Number: PO22-13-22 Expand Presenting Author: Dakota Dustin, The Ohio State University
Topical Area: Nutritional Epidemiology
Supported by: IAFNS Carbohydrate and Lipids Committees
For more information, see here.

ABSTRACT

Objectives: This study evaluated the association between a restricted carbohydrate diet ( < 45% energy from carbohydrate) and metabolic syndrome stratified by fatty acid classes in a nationally representative sample of U.S adults.

Methods: Data on food and nutrient intake, and markers of metabolic syndrome, were obtained from 19,078 respondents ≥20 y in the National Health and Nutrition Examination Survey (NHANES) 1999-2018. The National Cancer Institute's usual intake methodology was used to evaluate the associations between usual dietary intake and prevalent metabolic syndrome.

Results: Compared to individuals that met all AMDR macronutrient recommendations, the odds of having metabolic syndrome were 1.085 (95%CI: 1.077-1.094) times higher among those that consumed a restricted carbohydrate diet (P < 0.001) and 1.115 (1.153-1.156) times higher for those that met only current recommendations for total carbohydrates (P < 0.001). Higher fat intake, regardless of class, was associated with increased likelihood of metabolic syndrome among individuals that consumed restricted carbohydrate diets but not among individuals that met current carbohydrate recommendations.

Conclusions: The likelihood of prevalent metabolic syndrome was moderately higher (8.5%) among individuals that consumed restricted carbohydrate diets compared to individuals that met all macronutrient recommendations. High intake of fat of any class was associated with increased likelihood of metabolic syndrome in those consuming a restricted carbohydrate diet.

Funding Sources: This work was supported by the Institute for the Advancement of Food and Nutrition Sciences (IAFNS) Carbohydrate and Lipid Committees. IAFNS is a nonprofit science organization that pools funding from industry collaborators and advances science through the in-kind and financial contributions from public and private sector participants. IAFNS had no role in the design, analysis, interpretation, or presentation of the data and results.

 

Associations Between Essential Amino Acids and Functional Health Outcomes in Older Adults: Analysis of the National Health and Nutrition Examination Survey, 2001-2018:Abstract Presentation Number: PO22-09-22 Expand Abstract Topical Area: Nutritional Epidemiology, FSU Metabolic Kitchen & Diet Assessment Center
Presenting Author: Susan Cheung
Supported by: IAFNS Protein Committee
For more information, see here.

ABSTRACT:

Objectives: Little is known about the relationships between habitual essential amino acid (EAA) intake and functional health in older US adults. This cross-sectional study investigates associations between usual EAA intakes and body composition, muscle strength, and physical function in US adults ≥ 65 y.

Methods: The Food and Nutrient Database for Dietary Studies (FNDDS) 2001-2018 was linked to USDA FoodData Central to access existing EAA composition data for FNDDS ingredients. FNDDS ingredients without existing EAA data were matched to similar ingredient codes with available EAA data. Usual intakes of EAA, leucine, lysine, and sulfur-containing AAs (SAA; methionine + cysteine) from NHANES 2001-2018 were calculated as relative [mg/kg ideal body weight (IBW)/d] and absolute (g/d) intakes for individuals ≥ 65 y (n=10,843). Dependent variables were muscle strength measured by isometric grip test, BMI, waist circumference (WC), DXA-measured appendicular lean mass and whole-body fat mass, and self-reported physical function. Regression analyses were used to determine covariate-adjusted relationships between EAA, leucine, lysine, and SAA intake and functional health outcomes. P < 0.0013 was considered significant.

Results: Absolute and relative EAA, leucine, lysine, and SAA intakes were not associated with muscle strength or self-reported physical function in males or females or with body composition in males. Absolute EAA intakes (per g) were associated with WC in females (β ± SEM, 2.1 ± 0.6 cm, P = 0.0007). Absolute lysine intakes (per g) were associated with BMI (3.0 ± 0.7 kg/m2, P < 0.0001) and WC (7.0 ± 1.7 cm, P = 0.0001) in females. Relative EAA, leucine, and lysine intakes (per mg/kg IBW) were associated with BMI (0.07 ± 0.02, 0.26 ± 0.07, and 0.25 ± 0.04 kg/m2, respectively; P ≤ 0.0004 for all) and WC (0.18 ± 0.03, 0.81 ± 0.17, and 0.64 ± 0.10 cm, respectively; P < 0.0001 for all) in females. Relative lysine intakes (per mg/kg IBW) were associated with whole body fat mass (0.24 ± 0.07 kg, P = 0.0006) in females.

Conclusions: EAA intakes, particularly lysine, were positively associated with measures of adiposity in women ≥ 65 y. Investigating sources of lysine intake may provide insight about which foods or food groups are driving this relationship.

Funding Sources: IAFNS Protein Committee, USAMRDC, DoD Center Alliance for Nutrition and Dietary Supplements Research

Amino Acid Intake and Conformance With the Dietary Reference Intakes in the United States: Analysis of the National Health and Nutrition Examination Survey, 2001-2018: Abstract Presentation Number: PO22-06-22 Expand Abstract Topical Area: Nutritional Epidemiology
Presenting Author: Claire Berryman, Florida State University
Supported by: IAFNS Protein Committee
For more information, see here. ABSTRACT
Objectives: The lack of complete amino acid composition data in food composition databases has made determining population-wide amino acid intake difficult. This cross-sectional study characterizes habitual intakes of each amino acid and adherence to dietary requirements for each essential amino acid (EAA) by age, gender, and race/ethnicity in the US population.

Methods: Food and Nutrient Database for Dietary Studies ingredient codes with missing amino acid composition data were matched to similar ingredients with available data, so that amino acid composition could be determined for virtually 100% of foods reported in What We Eat in America, the dietary intake assessment component of NHANES. Amino acid intakes during 2-y cycles of NHANES 2001-2018 (n = 84,629; ≥ 2y) were calculated as relative [mg/kg of ideal body weight (IBW)/d] and absolute (g/d) intakes. Data from NHANES 2011-2018 were used to determine the percentage of the population consuming less than the Dietary Reference Intakes for each EAA by age, sex, and race/ethnicity.

Results: Relative intakes of EAAs were greatest in those 2-3 y (females: 1552 ± 9 and males: 1659 ± 9 mg/kg IBW/d) and lowest in those ≥ 80 y (females: 446 ± 2 and males: 461 ± 3 mg/kg IBW/d). Absolute intakes of EAAs were greatest in those 31-50 y (females: 31.4 ± 0.1 and males: 45.5 ± 0.1 g/d) and lowest in those 2-3 y (females: 22.4 ± 0.1 and males: 26.0 ± 0.1 g/d). In individuals 2-18 y and ≥ 19 y, relative intakes of EAAs were lowest in the NHB population (860 ± 16 and 505 ± 5 mg/kg IBW/d, respectively) and highest in the Asian population (994 ± 35 and 580 ± 7 mg/kg IBW/d, respectively). Less than 1% of individuals ≥ 19 y were not meeting the Estimated Average Requirements for each EAA.

Conclusions: Individual amino acid intakes in the US population exceed recommended minimum population requirements. Future studies can use the method described here to quantify habitual amino acid intake and examine relationships with health and disease.

Funding Sources: Institute for the Advancement of Food and Nutrition Sciences (IAFNS) Protein Committee, US Army Medical Research and Development Command, and the Department of Defense Center Alliance for Nutrition and Dietary Supplements Research.

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